Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy

Y Jiang, H Zhang, J Wang, Y Liu, T Luo… - Journal of hematology & …, 2022 - Springer
Cancer microenvironment is critical for tumorigenesis and cancer progression. The
extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells …

Role of tumor microenvironment in cancer progression and therapeutic strategy

Q Wang, X Shao, Y Zhang, M Zhu, FXC Wang… - Cancer …, 2023 - Wiley Online Library
Cancer is now considered a tumor microenvironment (TME) disease, although it was
originally thought to be a cell and gene expression disorder. Over the past 20 years …

Mesenchymal stem cell-macrophage crosstalk and maintenance of inflammatory microenvironment homeostasis

D Lu, Y Xu, Q Liu, Q Zhang - Frontiers in cell and developmental …, 2021 - frontiersin.org
Macrophages are involved in almost every aspect of biological systems and include
development, homeostasis and repair. Mesenchymal stem cells (MSCs) have good clinical …

CXCL12/CXCR4 axis supports mitochondrial trafficking in tumor myeloma microenvironment

C Giallongo, I Dulcamare, D Tibullo, V Del Fabro… - Oncogenesis, 2022 - nature.com
Mesenchymal stromal cells (MSCs) within the protective microenvironment of multiple
myeloma (MM) promote tumor growth, confer chemoresistance and support metabolic needs …

Adipose tissue-derived mesenchymal stromal/stem cells, obesity and the tumor microenvironment of breast cancer

A Ritter, NN Kreis, SC Hoock, C Solbach, F Louwen… - Cancers, 2022 - mdpi.com
Simple Summary Adipose tissue is the major microenvironment of breast cancer. Adipose
tissue-derived mesenchymal stromal/stem cells (ASCs/MSCs) are key players in adipose …

Deciphering tumor niches: lessons from solid and hematological malignancies

SJC Mancini, K Balabanian, I Corre, J Gavard… - Frontiers in …, 2021 - frontiersin.org
Knowledge about the hematopoietic niche has evolved considerably in recent years, in
particular through in vitro analyzes, mouse models and the use of xenografts. Its complexity …

Exosomal miR-483-5p in bone marrow mesenchymal stem cells promotes malignant progression of multiple myeloma by targeting TIMP2

J Gu, M Wang, X Wang, J Li, H Liu, Z Lin… - Frontiers in Cell and …, 2022 - frontiersin.org
Bone marrow-derived mesenchymal stem cell (BMSC) is one crucial component of the
multiple myeloma (MM) microenvironment and supports the malignant progression of MM …

Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the …

F Roth‐Walter, IM Adcock, C Benito‐Villalvilla… - Allergy, 2024 - Wiley Online Library
The accumulation of senescent cells drives inflammaging and increases morbidity of chronic
inflammatory lung diseases. Immune responses are built upon dynamic changes in cell …

Lipofilling in breast oncological surgery: a safe opportunity or risk for cancer recurrence?

F Piccotti, I Rybinska, E Scoccia, C Morasso… - International Journal of …, 2021 - mdpi.com
Lipofilling (LF) is a largely employed technique in reconstructive and esthetic breast surgery.
Over the years, it has demonstrated to be extremely useful for treatment of soft tissue defects …

The origins and generation of cancer-associated mesenchymal stromal cells: an innovative therapeutic target for solid tumors

W Li, J Yang, P Zheng, H Li, S Zhao - Frontiers in Oncology, 2021 - frontiersin.org
Cancer-associated mesenchymal stromal cells (CA-MSCs) have been isolated from various
types of tumors and are characterized by their vigorous pro-tumorigenic functions. However …