The liver is a central organ for homeostasis with unique regenerative capacities. Mature
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …

Spermatogonial stem cells (SSCs) are the most primitive spermatogonia in the testis and
have an essential role to maintain highly productive spermatogenesis by self-renewal and …

BACKGROUND & AIMS: Cancer progression/metastases and embryonic development
share many properties including cellular plasticity, dynamic cell motility, and integral …

Spermatogonial stem cells (SSCs) self-renew and produce large numbers of committed
progenitors that are destined to differentiate into spermatozoa throughout life. However, the …

Acute liver failure (ALF) is a rare but challenging clinical syndrome with multiple causes; a
specific etiology cannot be identified in 15% of adult and 50% of pediatric cases. The course …

Entity or Function? specific adult stem cell may need to be expanded. Accordingly, adult
stem cells may not only act locally in the tissues in which they reside, but may also be …

The liver has the unique capacity to regulate its growth and mass. In rodents and humans, it
grows rapidly after resection of more than 50% of its mass. This growth process, as well as …

Human hepatic stem cells (hHpSCs), which are pluripotent precursors of hepatoblasts and
thence of hepatocytic and biliary epithelia, are located in ductal plates in fetal livers and in …

Background: Biliary tract cancers (BTC) are relatively rare malignant tumours with poor
prognosis. It is known from other solid neoplasms that antitumour inflammatory response …

Multipotent stem/progenitors are present in peribiliary glands of extrahepatic biliary trees
from humans of all ages and in high numbers in hepato‐pancreatic common duct, cystic …