Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

Podosomes and invadopodia are actin-based dynamic protrusions of the plasma membrane
of metazoan cells that represent sites of attachment to—and degradation of—the …

Atherosclerosis, cancer, and various chronic fibrotic conditions are characterized by an
increase in the migratory behavior of resident cells and the enhanced invasion of assorted …

Physical forces regulate numerous biological processes during development, physiology,
and pathology. Forces between the external environment and intracellular actin cytoskeleton …

Metastasis is responsible for most cancer-associated deaths. Accumulating evidence based
on 3D migration models has revealed a diversity of invasive migratory schemes reflecting …

The ability to degrade extracellular matrix is critical for tumor cells to invade and
metastasize. Recent studies show that tumor cells use specialized actin-based membrane …

Invadopodia are actin-rich protrusions that degrade the extracellular matrix and are required
for penetration through the basement membrane, stromal invasion and intravasation …

Unraveling the mechanisms that govern the formation and function of invadopodia is
essential towards the prevention of cancer spread. Here, we characterize the ultrastructural …

The basement membrane is a dense, highly cross-linked, sheet-like extracellular matrix that
underlies all epithelia and endothelia in multicellular animals. During development …

Osteoclasts are the cells responsible for physiological bone resorption. A specific
organization of their most prominent cytoskeletal structures, podosomes, is crucial for the …