The potential of PARP inhibitors in targeted cancer therapy and immunotherapy
J Hunia, K Gawalski, A Szredzka… - Frontiers in molecular …, 2022 - frontiersin.org
DNA damage response (DDR) deficiencies result in genome instability, which is one of the
hallmarks of cancer. Poly (ADP-ribose) polymerase (PARP) enzymes take part in various …
hallmarks of cancer. Poly (ADP-ribose) polymerase (PARP) enzymes take part in various …
Role of PARP in TNBC: Mechanism of inhibition, clinical applications, and resistance
Triple-negative breast cancer is a combative cancer type with a highly inflated histological
grade that leads to poor theragnostic value. Gene, protein, and receptor-specific targets …
grade that leads to poor theragnostic value. Gene, protein, and receptor-specific targets …
Inhibitors of PARP: Number crunching and structure gazing
Selective inhibitors of PARP1 and PARP2 (PARP1/2) are used to treat cancer patients with
deficiencies in the repair of DNA via homologous recombination. Here we provide a …
deficiencies in the repair of DNA via homologous recombination. Here we provide a …
The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer
J Rudolph, UM Muthurajan, M Palacio, J Mahadevan… - Molecular cell, 2021 - cell.com
PARP1 is a key player in the response to DNA damage and is the target of clinical inhibitors
for the treatment of cancers. Binding of PARP1 to damaged DNA leads to activation wherein …
for the treatment of cancers. Binding of PARP1 to damaged DNA leads to activation wherein …
PARP power: a structural perspective on PARP1, PARP2, and PARP3 in DNA damage repair and nucleosome remodelling
L van Beek, É McClay, S Patel, M Schimpl… - International journal of …, 2021 - mdpi.com
Poly (ADP-ribose) polymerases (PARP) 1-3 are well-known multi-domain enzymes,
catalysing the covalent modification of proteins, DNA, and themselves. They attach mono-or …
catalysing the covalent modification of proteins, DNA, and themselves. They attach mono-or …
HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase
Poly (ADP-ribose) polymerase 1 (PARP1) is an important player in the response to DNA
damage. Recently, Histone PARylation Factor (HPF1) was shown to be a critical modulator …
damage. Recently, Histone PARylation Factor (HPF1) was shown to be a critical modulator …
The contribution of PARP1, PARP2 and poly (ADP-ribosyl) ation to base excision repair in the nucleosomal context
MM Kutuzov, EA Belousova, TA Kurgina… - Scientific reports, 2021 - nature.com
The regulation of repair processes including base excision repair (BER) in the presence of
DNA damage is implemented by a cellular signal: poly (ADP-ribosyl) ation (PARylation) …
DNA damage is implemented by a cellular signal: poly (ADP-ribosyl) ation (PARylation) …
Slow Dissociation from the PARP1–HPF1 Complex Drives Inhibitor Potency
PARP1, upon binding to damaged DNA, is activated to perform poly ADP-ribosylation
(PARylation) on itself and other proteins, which leads to relaxation of chromatin and …
(PARylation) on itself and other proteins, which leads to relaxation of chromatin and …
[HTML][HTML] ADP-ribose contributions to genome stability, and PARP enzyme trapping on sites of DNA damage; paradigm shifts for a coming-of-age modification
É Rouleau-Turcotte, JM Pascal - Journal of Biological Chemistry, 2023 - Elsevier
ABSTRACT ADP-ribose is a versatile modification that plays a critical role in diverse cellular
processes. The addition of this modification is catalyzed by ADP-ribosyltransferases, among …
processes. The addition of this modification is catalyzed by ADP-ribosyltransferases, among …
[HTML][HTML] The fast-growing business of Serine ADP-ribosylation
EJ Longarini, I Matic - Dna Repair, 2022 - Elsevier
ADP-ribosylation (ADPr) is a widespread post-translational modification (PTM) which
encompasses all kingdoms of life. It is employed by bacteria and viruses in their war against …
encompasses all kingdoms of life. It is employed by bacteria and viruses in their war against …