NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration

GZ Zhang, MQ Liu, HW Chen, ZL Wu, YC Gao… - Cell …, 2021 - Wiley Online Library
Intervertebral disc degeneration (IDD) is a common clinical degenerative disease of the
spine. A series of factors, such as inflammation, oxidative stress and mechanical stress …

[HTML][HTML] Ageing–oxidative stress, PTMs and disease

T Ebert, N Tran, L Schurgers, P Stenvinkel… - Molecular aspects of …, 2022 - Elsevier
Post-translational modifications (PTMs) have been proposed as a link between the oxidative
stress-inflammation-ageing trinity, thereby affecting several hallmarks of ageing …

Mitochondrial quality control in intervertebral disc degeneration

Y Song, S Lu, W Geng, X Feng, R Luo, G Li… - … & molecular medicine, 2021 - nature.com
Intervertebral disc degeneration (IDD) is a common and early-onset pathogenesis in the
human lifespan that can increase the risk of low back pain. More clarification of the …

Sirtuins and intervertebral disc degeneration: roles in inflammation, oxidative stress, and mitochondrial function

GZ Zhang, YJ Deng, QQ Xie, EH Ren, ZJ Ma, XG He… - Clinica chimica acta, 2020 - Elsevier
Intervertebral disc degeneration (IDD) is one of the main causes of low back pain, which
seriously reduces the quality of life of patients and places a heavy economic burden on their …

[HTML][HTML] Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation

Y Zhao, C Qiu, W Wang, J Peng, X Cheng… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Intervertebral disc (IVD) degeneration is a common degenerative disease that
can lead to collapse or herniation of the nucleus pulposus (NP) and result in radiculopathy …

Quercetin suppresses apoptosis and attenuates intervertebral disc degeneration via the SIRT1-autophagy pathway

D Wang, X He, D Wang, P Peng, X Xu… - Frontiers in cell and …, 2020 - frontiersin.org
Intervertebral disc degeneration (IDD) has been generally accepted as the major cause of
low back pain (LBP), which causes an enormous socioeconomic burden. Previous studies …

m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency

G Li, R Luo, W Zhang, S He, B Wang… - Clinical and …, 2022 - Wiley Online Library
Background The intervertebral disc (IVD) degeneration is the leading cause of low back
pain, which accounts for a main cause of disability. N6‐methyladenosine (m6A) is the most …

Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degeneration

J Xu, T Shao, J Lou, J Zhang, C Xia - Frontiers in pharmacology, 2023 - frontiersin.org
Intervertebral disc degeneration (IVDD) refers to the aging and degenerative diseases of
intervertebral disc components such as nucleus pulposus, annulus fibrosus, and cartilage …

Hexavalent chromium induces mitochondrial dynamics disorder in rat liver by inhibiting AMPK/PGC-1α signaling pathway

Q Yang, B Han, J Xue, Y Lv, S Li, Y Liu, P Wu… - Environmental …, 2020 - Elsevier
Occupational exposure to hexavalent chromium (Cr (VI)) can cause cytotoxicity and
carcinogenicity. In this study, we established a liver injury model in rats via intraperitoneal …

The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn2+ trafficking

Y Song, H Liang, G Li, L Ma, D Zhu, W Zhang, B Tong… - Autophagy, 2024 - Taylor & Francis
Intervertebral disc degeneration (IDD) is the most critical pathological factor in the
development of low back pain. The maintenance of nucleus pulposus (NP) cell and …