Synovial tissue macrophages (STMs) were principally recognized as having a pro-
inflammatory role in rheumatoid arthritis (RA), serving as the main producers of pathogenic …

Hyperactivation of immune responses resulting in excessive release of pro-inflammatory
mediators in alveoli/lung structures is the principal pathological feature of coronavirus …

Myocardial infarction is a leading cause of death worldwide. Although advances have been
made in acute treatment, an incomplete understanding of remodelling processes has limited …

Dysregulated mitochondrial function is a hallmark of immune-mediated inflammatory
diseases. Cytochrome c oxidase (C c O), which mediates the rate-limiting step in …

Macrophages regulate protective immune responses to infectious microbes, but aberrant
macrophage activation frequently drives pathological inflammation. To identify regulators of …

Frozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human
disease, which distinguishes the condition from most fibrotic diseases that are progressive …

Most accepted definitions of reactive arthritis (ReA) consider it a type of spondyloarthritis
(SpA) precipitated by a gut or urogenital infection. A wider definition considers any arthritis …

Human ACE2 Human angiotensin converting enzyme 2 (hACE2) is the key cell attachment
and entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with …

Vaccination has been a game changer in our efforts to address the coronavirus disease
2019 (COVID-19) pandemic. However, the disease might still represent a clinical crisis for …

Inflammation is a life-saving immune reaction occurring in response to invading pathogens.
Nonetheless, inflammation can also occur in an uncontrolled, unrestricted manner, leading …