The epigenome has been heralded as a key'missing piece'of the aetiological puzzle for
complex phenotypes across the biomedical sciences. The standard research approaches …

It has become clear that early life (including in utero exposures) is a key window of
vulnerability during which environmental exposures can alter developmental trajectories …

Host-associated microbial communities are influenced by both host genetics and
environmental factors. However, factors controlling the human oral microbiome and their …

Epigenetics is one of the most rapidly expanding fields in the life sciences. Its rise is
frequently framed as a revolutionary turn that heralds a new epoch both for gene-based …

The intrauterine environment has the potential to “program” the developing fetus in a way
that can be potentially deleterious to later health. While in utero environmental/stochastic …

To address the question of how microbial diversity and function in the oral cavities of
children relates to caries diagnosis, we surveyed the supragingival plaque biofilm …

Traditionally, it has been widely acknowledged that genes together with adult lifestyle factors
determine the risk of developing some metabolic diseases such as insulin resistance …

Epidemiological studies have led scientists to postulate the developmental origins of health
and disease hypothesis for noncommunicable diseases such as diabetes, cardiovascular …

Monozygotic (identical) twins have been widely used in genetic studies to determine the
relative contributions of heredity and the environment in human diseases. Discordance in …

DNA methylation patterns are characterized by highly conserved developmental programs,
but allow for divergent gene expression resulting from stochastic epigenetic drift or divergent …