[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)

RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

The vasoprotective axes of the renin-angiotensin system: physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases

XC Li, J Zhang, JL Zhuo - Pharmacological research, 2017 - Elsevier
The renin-angiotensin system (RAS) is undisputedly one of the most prominent endocrine
(tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) vasoactive …

Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets

F Jiang, J Yang, Y Zhang, M Dong, S Wang… - Nature Reviews …, 2014 - nature.com
The renin–angiotensin system (RAS) has pivotal roles in the regulation of normal physiology
and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2 …

Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation

J Totoń-Żurańska, TP Mikolajczyk, B Saju… - Clinical …, 2024 - portlandpress.com
Optimal vascular structure and function are essential for maintaining the physiological
functions of the cardiovascular system. Vascular remodelling involves changes in vessel …

Angiotensin-(1–7)

RA Santos - Hypertension, 2014 - Am Heart Assoc
Santos Cardiovascular Actions of Angiotensin-(1–7) 1139 in caveolin 3 expression and a
decrease in heat shock protein 90. 28 These 2 alterations may lead to a decrease in eNOS …

The pathophysiological roles of the renin–angiotensin system in the gastrointestinal tract

M Garg, PW Angus, LM Burrell, C Herath… - Alimentary …, 2012 - Wiley Online Library
Background The renin‐angiotensin system (RAS) is a homeostatic pathway widely known to
regulate cardiovascular and renal physiology; however, little is known about its influence in …

ACE2-Ang-(1-7)-Mas axis in brain: a potential target for prevention and treatment of ischemic stroke

T Jiang, L Gao, J Lu, YD Zhang - Current neuropharmacology, 2013 - ingentaconnect.com
The renin-angiotensin system (RAS) in brain is a crucial regulator for physiological
homeostasis and diseases of cerebrovascular system, such as ischemic stroke …

Mas receptor: a potential strategy in the management of ischemic cardiovascular diseases

A Molaei, E Molaei, AW Hayes, G Karimi - Cell Cycle, 2023 - Taylor & Francis
MasR is a critical element in the RAS accessory pathway that protects the heart against
myocardial infarction, ischemia-reperfusion injury, and pathological remodeling by …

Heat shock prevents insulin resistance–induced vascular complications by augmenting angiotensin-(1-7) signaling

PA Karpe, K Tikoo - Diabetes, 2014 - Am Diabetes Assoc
We have investigated the role of heat shock (HS) in preventing insulin resistance–induced
endothelial dysfunction. To the best of our knowledge, we report here for the first time that …

Targeting the ACE2–Ang-(1–7) pathway in cardiac fibroblasts to treat cardiac remodeling and heart failure

M Iwata, RT Cowling, SJ Yeo, B Greenberg - Journal of molecular and …, 2011 - Elsevier
Fibroblasts play a pivotal role in cardiac remodeling and the development of heart failure
through the deposition of extra-cellular matrix (ECM) proteins and also by affecting …