HIV-1 envelope glycoprotein [Env; trimeric (gp160) 3 cleaved to (gp120/gp41) 3] attaches
the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate …

The structure of a protein complex together with information about its affinity and other
thermodynamic characteristics provide a “frozen” view of the complex. This picture ignores …

The few antibodies that can potently neutralize human immunodeficiency virus type 1 (HIV-
1) recognize the limited number of envelope glycoprotein epitopes exposed on infectious …

The AIDS pandemic continues to spread unchecked in many parts of the world, with greater
than 34 million individuals currently infected with human immunodeficiency virus (HIV) …

Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

HIV infection is initiated by the selective interaction between the cellular receptor CD4 and
gp120, the external envelope glycoprotein of the virus. We used analytical …

The ability of HIV-1 to use dendritic cells (DCs) for transport and to transfer virus to activated
T cells in the lymph node may be crucial in early HIV-1 pathogenesis. We have …

The glycoprotein (gp) 120 subunit is an important part of the envelope spikes that decorate
the surface of HIV-1 and a major target for neutralizing antibodies. However, immunization …

The current general model of HIV viral entry involves the binding of the trimeric viral
envelope glycoprotein gp120/gp41 to cell surface receptor CD4 and chemokine co-receptor …

Despite the enormous effort in the development of effective vaccines against HIV-1, no
vaccine candidate has elicited broadly neutralizing antibodies in humans. Thus, generation …