Marfan syndrome is a widespread disorder of connective tissue. It is characterized by
systemic and ocular features due to mutations in the fibrillin gene. Awareness and prompt …

Abstract" The Diseases of the Horny-coat of The Eye", known today as keratoconus, is a
progressive, multifactorial, non-inflammatory ectatic corneal disorder that is characterized by …

Context Fluoroquinolones are commonly prescribed classes of antibiotics. Despite
numerous case reports of ocular toxicity, a pharmacoepidemiological study of their ocular …

Marfan syndrome (MFS) is an autosomal dominant, age-related but highly penetrant
condition with substantial intrafamilial and interfamilial variability. MFS is caused by …

Marfan syndrome is an autosomal dominant genetic connective tissue disorder that results
from mutations in the fibrillin-1 gene located on chromosome band 15q15–21. Fibrillin, a …

Background To study biometric and structural ocular manifestations of Marfan syndrome
(MFS). Methods Observational, retrospective, comparative cohort study in a tertiary referral …

Rhegmatogenous retinal detachment (RRD) is a sight threatening condition that warrants
immediate surgical intervention. To date, 29 genes have been associated with monogenic …

Purpose: To study ocular manifestations of Marfan syndrome in children and adolescents.
Methods: Retrospective comparative cohort study on consecutive patients up to age 17 …

Pediatric rhegmatogenous retinal detachments are rare, accounting for less than ten percent
of all rhegmatogenous retinal detachments. While most retinal detachments in the adult …

Fibrillin-1 is an extracellular matrix protein that assembles into microfibrils that provide
critical functions in large blood vessels and other tissues. Mutations in the fibrillin-1 gene are …