Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

Traumatic brain injury, a leading cause of mortality and morbidity, is divided into three
grades of severity: mild, moderate, and severe, based on the Glasgow Coma Scale, the loss …

Corticobasal degeneration (CBD) is a neurodegenerative tauopathy—a class of disorders in
which the tau protein forms insoluble inclusions in the brain—that is characterized by motor …

Lowering total tau levels is an attractive therapeutic strategy for Alzheimer's disease and
other tauopathies. High-throughput screening in neurons derived from human induced …

▪ Abstract The defining neuropathological characteristics of Alzheimer's disease are
abundant filamentous tau lesions and deposits of fibrillar amyloid β peptides. Prominent …

Tau proteins belong to the family of microtubule-associated proteins. They are mainly
expressed in neurons where they play an important role in the assembly of tubulin …

One hundred years ago a small group of psychiatrists described the abnormal protein
deposits in the brain that define the most common neurodegenerative diseases. Over the …

Abstract Avila, Jesús, José J. Lucas, Mar Pérez, and Félix Hernández. Role of Tau Protein in
Both Physiological and Pathological Conditions. Physiol Rev 84: 361–384, 2004; …

The accumulation of α-synuclein aggregates is the hallmark of Parkinson's disease, and
more generally of synucleinopathies. The accumulation of tau aggregates however is …

A working group supported by the Office of Rare Diseases of the National Institutes of Health
formulated neuropathologic criteria for corticobasal degeneration (CBD) that were …