Organoids are 3D cell culture systems derived from human pluripotent stem cells that
contain tissue resident cell types and reflect features of early tissue organization. Neural …

Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological
synapse structure and function, and can be either the cause or the consequence in specific …

Although Huntington's disease is a late-manifesting neurodegenerative disorder, both
mouse studies and neuroimaging studies of presymptomatic mutation carriers suggest that …

Harnessing the potential of human embryonic stem cells to mimic normal and aberrant
development with standardized models is a pressing challenge. Here we use micropattern …

The complexity of affected brain regions and cell types is a challenge for Huntington's
disease (HD) treatment. Here we use single nucleus RNA sequencing to investigate …

Organoids and cells in organ‐on‐chip platforms replicate higher‐level anatomical,
physiological, or pathological states of tissues and organs. These technologies are widely …

Organoids represent one of the most important advancements in the field of stem cells
during the past decade. They are three-dimensional in vitro culturing models that originate …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Neurological disorders have emerged as a predominant healthcare concern in recent years
due to their severe consequences on quality of life and prevalence throughout the world …

Huntington disease is an autosomal dominant inherited brain disorder that typically
becomes manifest in adulthood. Juvenile‐onset Huntington disease refers to approximately …