[HTML][HTML] The lymphatic vasculature in the 21st century: novel functional roles in homeostasis and disease
Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …
[HTML][HTML] Role of tumor microenvironment in tumorigenesis
M Wang, J Zhao, L Zhang, F Wei, Y Lian, Y Wu… - Journal of …, 2017 - ncbi.nlm.nih.gov
Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation,
progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and …
progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and …
Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system
X Li, L Qi, D Yang, SJ Hao, F Zhang, X Zhu, Y Sun… - Nature …, 2022 - nature.com
Recent studies have demonstrated that brain meningeal lymphatic vessels (MLVs) act as a
drainage path directly into the cervical lymph nodes (CLNs) for macromolecules contained …
drainage path directly into the cervical lymph nodes (CLNs) for macromolecules contained …
Lymphatic malformations: genetics, mechanisms and therapeutic strategies
Lymphatic vessels maintain tissue fluid homeostasis by returning to blood circulation
interstitial fluid that has extravasated from the blood capillaries. They provide a trafficking …
interstitial fluid that has extravasated from the blood capillaries. They provide a trafficking …
[HTML][HTML] Lymphatic vessel network structure and physiology
The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …
which has the holistic function to maintain the local physiologic environment for every cell in …
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
HR Warren, E Evangelou, CP Cabrera, H Gao, M Ren… - Nature …, 2017 - nature.com
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse …
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse …
A copy number variation map of the human genome
A major contribution to the genome variability among individuals comes from deletions and
duplications—collectively termed copy number variations (CNVs)—which alter the diploid …
duplications—collectively termed copy number variations (CNVs)—which alter the diploid …
GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity
MA Spinner, LA Sanchez, AP Hsu… - Blood, The Journal …, 2014 - ashpublications.org
Haploinsufficiency of the hematopoietic transcription factor GATA2 underlies monocytopenia
and mycobacterial infections; dendritic cell, monocyte, B, and natural killer (NK) lymphoid …
and mycobacterial infections; dendritic cell, monocyte, B, and natural killer (NK) lymphoid …
Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy
We report germline missense mutations in ETV6 segregating with the dominant transmission
of thrombocytopenia and hematologic malignancy in three unrelated kindreds, defining a …
of thrombocytopenia and hematologic malignancy in three unrelated kindreds, defining a …
The genomic landscape of juvenile myelomonocytic leukemia
E Stieglitz, AN Taylor-Weiner, TY Chang, LC Gelston… - Nature …, 2015 - nature.com
Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm (MPN) of
childhood with a poor prognosis. Mutations in NF1, NRAS, KRAS, PTPN11 or CBL occur in …
childhood with a poor prognosis. Mutations in NF1, NRAS, KRAS, PTPN11 or CBL occur in …