Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

Enlarged fat cells in obese adipose tissue diminish capacity to store fat and are resistant to
the anti-lipolytic effect of insulin. Insulin resistance (IR)-associated S-nitrosylation of insulin …

Fat and carbohydrate are important fuels for aerobic exercise and there can be reciprocal
shifts in the proportions of carbohydrate and fat that are oxidized. The interaction between …

Long-chain fatty acids and lipids serve a wide variety of functions in mammalian
homeostasis, particularly in the formation and dynamic properties of biological membranes …

This review summarizes how fatty acid (FA) oxidation is regulated in skeletal muscle during
exercise. From the available evidence it seems that acetyl-CoA availability in the …

High-intensity aerobic interval training (HIIT) is a compromise between time-consuming
moderate-intensity training and sprint-interval training requiring all-out efforts. However …

Fatty acid oxidation is highly regulated in skeletal muscle and involves several sites of
regulation, including the transport of fatty acids across both the plasma and mitochondrial …

During exercise, the supply of adenosine triphosphate (ATP) is essential for the energy-
dependent processes that underpin ongoing contractile activity. These pathways involve …

PGC-1α overexpression in skeletal muscle, in vivo, has yielded disappointing and
unexpected effects, including disrupted cellular integrity and insulin resistance. These …

The performance of prolonged (> 90 min), continuous, endurance exercise is limited by
endogenous carbohydrate (CHO) stores. Accordingly, for many decades, sports nutritionists …