Two sides of the same coin: Protective versus pathogenic CD4+ resident memory T cells

AE Oja, RAW van Lier, P Hombrink - Science immunology, 2022 - science.org
The ability of the adaptive immune system to form memory is key to providing protection
against secondary infections. Resident memory T cells (TRM) are specialized T cell …

Liver-resident memory T cells: life in lockdown

LJ Pallett, MK Maini - Seminars in Immunopathology, 2022 - Springer
A subset of memory T cells has been identified in the liver with a tissue-resident profile and
the capacity for long-term 'lockdown'. Here we review how they are retained in, and adapted …

Psoriatic and rheumatoid arthritis joints differ in the composition of CD8+ tissue-resident memory T cell subsets

GAM Povoleri, LE Durham, EH Gray, S Lalnunhlimi… - Cell Reports, 2023 - cell.com
Summary CD69+ CD103+ tissue-resident memory T (T RM) cells are important drivers of
inflammation. To decipher their role in inflammatory arthritis, we apply single-cell, high …

Tissue-resident immunity in the female and male reproductive tract

D Yüzen, PC Arck, K Thiele - Seminars in immunopathology, 2022 - Springer
The conception of how the immune system is organized has been significantly challenged
over the last years. It became evident that not all lymphocytes are mobile and recirculate …

A novel human skin tissue model to study varicella-zoster virus and human cytomegalovirus

MG Lloyd, NA Smith, M Tighe, KL Travis, D Liu… - Journal of …, 2020 - Am Soc Microbiol
The herpesviruses varicella-zoster virus (VZV) and human cytomegalovirus (HCMV) are
endemic to humans. VZV causes varicella (chicken pox) and herpes zoster (shingles), while …

Advancements in the characterization of tissue resident memory T cells in skin disease

L Li, PP Liu, C Chen, B Yan, X Chen, J Li, C Peng - Clinical Immunology, 2022 - Elsevier
The newly discovered subset of memory T cells, tissue resident memory T (TRM) cells,
reside in peripheral tissues for a long time, contributing to a rapid immune response and …

Joint-specific memory, resident memory T cells and the rolling window of opportunity in arthritis

MH Chang, RC Fuhlbrigge, PA Nigrovic - Nature Reviews …, 2024 - nature.com
In rheumatoid arthritis, juvenile idiopathic arthritis and other forms of inflammatory arthritis,
the immune system targets certain joints but not others. The pattern of joints affected varies …

Should I stay or should I go—Reconciling clashing perspectives on CD4+ tissue-resident memory T cells

FR Carbone, T Gebhardt - Science Immunology, 2019 - science.org
Should I stay or should I go—Reconciling clashing perspectives on CD4+ tissue-resident
memory T cells | Science Immunology news careers commentary Journals Science Science …

Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells

SA Yukl, S Khan, TH Chen, M Trapecar, F Wu… - Journal of …, 2020 - Am Soc Microbiol
Latent HIV infection is the main barrier to cure, and most HIV-infected cells reside in the gut,
where distinct but unknown mechanisms may promote viral latency. Transforming growth …

Donor tissue-resident memory-like T and NK cells generate a transient peripheral chimerism in lung transplant recipients, potentially protective from chronic lung …

R Bellmàs-Sanz, AM Hitz, B Wiegmann, JF Kühne… - bioRxiv, 2023 - biorxiv.org
Lung transplantation (LTx) is the only definite treatment option of patients suffering from end-
stage lung disease. Long-term outcome is hampered by chronic allograft dysfunction …