Colorectal cancer (CRC) is highly heterogeneous at the genetic and molecular level, which
has major repercussions on the efficacy of immunotherapy. A small subset of CRCs exhibit …

Simple Summary Colorectal cancer (CRC) is the third most common cancer worldwide.
Metastasis to secondary organs, such as the liver and lungs, is a key driver of CRC-related …

Chronic inflammation is a known risk factor for gastrointestinal cancer. The evidence that
nonsteroidal anti-inflammatory drugs suppress the incidence, growth, and metastasis of …

Fusobacterium nucleatum (F. nucleatum) is a Gram-negative obligate anaerobe bacterium
in the oral cavity and plays a role in several oral diseases, including periodontitis and …

Colorectal cancer (CRC) is one of the most common cancer types and represents a major
therapeutic challenge. Although initial events in colorectal carcinogenesis are relatively well …

Among all immune cells, dendritic cells (DC) are the most potent APCs in the immune
system and are central players of the adaptive immune response. There are phenotypically …

Background Plasmacytoid dendritic cells (pDCs) play a key role in the induction and
maintenance of antitumor immunity. Conversely, they can act as tolerogenic DCs by …

The outcome of tumors results from genetic and epigenetic modifications of the transformed
cells and also from the interactions of the malignant cells with their tumor microenvironment …

Chronic inflammation is a risk factor for gastrointestinal cancer and other diseases. Most
studies have focused on cytokines and chemokines as mediators connecting chronic …

Solid tumors are constituted of a variety of cellular components, including bona fide
malignant cells as well as endothelial, structural and immune cells. On one hand, the tumor …