▪ Abstract The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also
cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin …

Prostanoids are cyclic, oxygenated products ofω3 andω6 20-and 22-carbon essential fatty
acids (FAs) that are formed enzymatically through “cyclooxygenases”. Prostaglandin …

Omega-6 (ω-6) polyunsaturated fatty acids (PUFA), abundant in the Western diet, are
precursors for a number of key mediators of inflammation including the 2-series of …

'Eicosanoid'is a term coined to describe compounds derived from C 20 fatty acids [1]. The
term is now generally used to identify the paracrine hormones derived from free arachidonic …

ABSTRACT Phospholipase A 2 (PLA 2) plays crucial roles in diverse cellular responses,
including phospholipid digestion and metabolism, host defense and signal transduction …

Dietary fish oil containing ω3 highly unsaturated fatty acids has cardioprotective and anti-
inflammatory effects. Prostaglandins (PGs) and thromboxanes are produced in vivo both …

Publisher Summary The chapter compares and contrasts the structural and kinetic
properties of prostaglandin endoperoxide H synthase-1 (PGHS-1) and-2. It also discusses …

Antimicrobial peptides, human β‐defensins (hBD‐1/‐2), and LL‐37 (a peptide of human
cathelicidin CAP18) are predominately expressed at epithelial tissues, where they …

Seventeen pungent oleoresin principles of ginger (Zingiber officinale, Roscoe) and synthetic
analogues were evaluated for inhibition of cyclooxygenase-2 (COX-2) enzyme activity in the …

Prostanoids represent a group of lipid mediators that are produced from arachidonic acid via
the cyclooxygenase pathway. Once formed, the prostanoids are released from the cells and …