Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine
for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest …

Publisher Summary This chapter discusses the molecular mode of action of cytotoxic
alkaloids. Alkaloids comprise a class of secondary metabolites. Alkaloids have evolved in …

We describe enantioselective syntheses of strychnos and chelidonium alkaloids. In the first
case, indole acetic acid esters were established as excellent partner nucleophiles for …

Various bioactive ingredients have been extracted from Chinese herbal medicines (CHMs)
that affect tumor progression and metastasis. To further understand the mechanisms of …

The benzophenanthridine alkaloids sanguinarine, chelerythrine and chelidonine were
reported previously to provoke cell death in a variety of tumor cells suggesting their potential …

Zanthoxylum rhoifolium (Rutaceae) is a plant alkaloid that grows in South America and has
been used in Brazilian traditional medicine for the treatment of different health problems …

BACKGROUND: Search for new substances with antiproliferative activity towards melanoma
cells is important since malignant melanoma is notoriously resistant to conventional …

The benzocyclobutene (BCB) moiety is present in several bioactive natural products and
medicinally interesting molecules. BCB is also a valuable synthon for building a variety of …

Background Ukrain is an anticancer drug based on the extract of the plant Chelidonium
majus L. Numerous pre-clinical and clinical investigations seem to suggest that Ukrain is …

Abstract Background The anticancer drug Ukrain (NSC-631570) which has been specified
by the manufacturer as semisynthetic derivative of the Chelidonium majus L. alkaloid …