The blood–brain barrier (BBB) was first noted for its ability to prevent the unregulated
exchange of substances between the blood and the central nervous system (CNS). Over …

The" thrifty gene hypothesis" suggests we evolved genes for efficient food collection and fat
deposition to survive periods of famine and that now that food is continuously available …

Western lifestyles differ markedly from those of our hunter-gatherer ancestors, and these
differences in diet and activity level are often implicated in the global obesity pandemic …

Almost 50 years ago Neel proposed a hypothesis to explain the prevalence of obesity and
diabetes in modern society—the 'thrifty gene'hypothesis. The fundamental basis of the …

A novel hypothesis of obesity is suggested by consideration of diet-related inflammation and
evolutionary medicine. The obese homeostatically guard their elevated weight. In rodent …

Until recently, the reproductive ecology of human males has not been extensively
investigated, primarily as a result of the need for a theoretical framework based on the …

Human reproductive ecology (HRE) is the study of the mechanisms that link variation in
reproductive traits with variation in local habitats. Empirical and theoretical contributions …

Over the last 50 years there has been a major epidemic of obesity and associated co-
morbidities, the so-called 'metabolic syndrome', mostly in the western world but with an …

This review examines the proximate, ecological, and evolutionary determinants of energy
expenditure in humans and primates, with an emphasis on empirical measurements of total …

Human life histories are shaped by the allocation of metabolic energy to competing
physiological domains. A model framework of the pathways of energy allocation is described …