Lactoferrin from milk: Nutraceutical and pharmacological properties

F Giansanti, G Panella, L Leboffe, G Antonini - Pharmaceuticals, 2016 - mdpi.com
Lactoferrin is an iron-binding protein present in large quantities in colostrum and in breast
milk, in external secretions and in polymorphonuclear leukocytes. Lactoferrin's main function …

Lactoferrin: A glycoprotein involved in immunomodulation, anticancer, and antimicrobial processes

Q Rascón-Cruz, EA Espinoza-Sánchez… - Molecules, 2021 - mdpi.com
Lactoferrin is an iron binding glycoprotein with multiple roles in the body. Its participation in
apoptotic processes in cancer cells, its ability to modulate various reactions of the immune …

Synthetic antibiotic derived from sequences encrypted in a protein from human plasma

A Cesaro, MDT Torres, R Gaglione, E Dell'Olmo… - ACS …, 2022 - ACS Publications
Encrypted peptides have been recently found in the human proteome and represent a
potential class of antibiotics. Here we report three peptides derived from the human …

Lactoferrin as a nutraceutical protein from milk, an overview

BF Iglesias-Figueroa, EA Espinoza-Sánchez… - International dairy …, 2019 - Elsevier
Lactoferrin, a non-haeme iron-binding glycoprotein, known as the red fraction of milk, has
been recently called a nutraceutical protein. Lactoferrin protein participates in some …

ALA‐A2 Is a Novel Anticancer Peptide Inspired by Alpha‐Lactalbumin: A Discovery from a Computational Peptide Library, In Silico Anticancer Peptide Screening and …

T Lerksuthirat, P On‐yam, S Chitphuk… - Global …, 2023 - Wiley Online Library
Anticancer peptides (ACPs) are rising as a new strategy for cancer therapy. However,
traditional laboratory screening to find and identify novel ACPs from hundreds to thousands …

Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload

C Ge, H Huang, F Huang, T Yang… - Proceedings of the …, 2019 - National Acad Sciences
Substance P (SP) regulates multiple biological processes through its high-affinity neurokinin-
1 receptor (NK-1R). While the SP/NK-1R signaling axis is involved in the pathogenesis of …

The potential use of peptides in cancer treatment

B Yavari, R Mahjub, M Saidijam… - Current Protein and …, 2018 - ingentaconnect.com
Conventional chemotherapeutic drugs have significant limitations. For example, tumors may
develop resistance, cancers may relapse after treatment, and the drugs may induce …

Insights into the antimicrobial activity and cytotoxicity of engineered α-helical peptide amphiphiles

Z Ma, J Yang, J Han, L Gao, H Liu, Z Lu… - Journal of Medicinal …, 2016 - ACS Publications
Antimicrobial peptides (AMPs) have gained increasing attention, as they can overcome
recurring microbial invasions. However, their poor antimicrobial activity and potential …

Cathelicidin hCAP18/LL-37 promotes cell proliferation and suppresses antitumor activity of 1,25(OH)2D3 in hepatocellular carcinoma

H Zhang, J Zhen, R Zhang, Y Wanyan, K Liu… - Cell death …, 2022 - nature.com
Abstract Cathelicidin hCAP18/LL-37 can resist infection from various pathogens and is an
essential component of the human immune system. Accumulating evidence has indicated …

Nisin ZP, an Antimicrobial Peptide, Induces Cell Death and Inhibits Non-Small Cell Lung Cancer (NSCLC) Progression in vitro in 2D and 3D Cell Culture

SM Patil, NK Kunda - Pharmaceutical research, 2022 - Springer
Lung cancer is the leading cause of cancer deaths globally with most of the reported cases
(> 85%) associated with non-small cell lung cancer (NSCLC). Current therapies have …