FXR (NR1H4) modulating compounds

PA Blomgren, KS Currie, J Farand, C Gege… - US Patent …, 2019 - Google Patents
The present disclosure relates generally to compounds which bind to the NR1H4 receptor
(FXR) and act as agonists of FXR. The disclosure further relates to the use of the compounds …

FXR (NR1H4) modulating compounds

PA Blomgren, KS Currie, C Gege, JE Kropf… - US Patent …, 2019 - Google Patents
The present disclosure relates generally to compounds which bind to the NR1H4 receptor
(FXR) and act as agonists of FXR. The disclosure further relates to the use of the compounds …

Methods of generating trophectoderm and neurectoderm from human embryonic stem cells

PJ Sammak, R Mangoubi, TM Erb, S Mucko… - US Patent …, 2017 - Google Patents
2011-03-02 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …

Generation of Endocrine Progenitor Cells from Human Pluripotent Stem Cells Using Small Molecules

U Doehn, NS Christophersen… - US Patent App. 14/913,604, 2016 - Google Patents
US20160208215A1 - Generation of Endocrine Progenitor Cells from Human Pluripotent
Stem Cells Using Small Molecules - Google Patents US20160208215A1 - Generation of …

Fused pyrazine derivatives as A2A/A2B inhibitors

X Wang, Y Li, C Qi, L Wu, W Yao, W Zhu - US Patent 11,161,850, 2021 - Google Patents
2019-07-23 Assigned to INCYTE CORPORATION reassignment INCYTE CORPORATION
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …

Generating induced pluripotent stem cells and progenitor cells from fibroblasts

M Bhatia, E Szabo, S Rampalli-Deshpande… - US Patent …, 2016 - Google Patents
2013-03-22 Assigned to MCMASTER UNIVERSITY reassignment MCMASTER
UNIVERSITY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …

FXR (NR1H4) binding and activity modulating compounds

O Kinzel, C Steeneck, C Kremoser - US Patent 10,220,027, 2019 - Google Patents
The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and
act as agonists of FXR. The invention further relates to the use of the compounds for the …

FXR (NR1H4) binding and activity modulating compounds

O Kinzel, C Steeneck, C Kremoser - US Patent 10,485,795, 2019 - Google Patents
The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and
act as agonists of FXR. The invention further relates to the use of the compounds for the …

Mathematical image analysis based cell reprogramming with applications for epigenetic and non-epigenetic base induced pluripotent stem cell derivation

R Mangoubi, PJ Sammak, M Desai, N Lowry - US Patent 8,515,150, 2013 - Google Patents
US8515150B2 - Mathematical image analysis based cell reprogramming with applications for
epigenetic and non-epigenetic base induced pluripotent stem cell derivation - Google Patents …

Recent Progress on Chemical Biology of Pluripotent Stem Cell Selfrenewal, Reprogramming and Cardiomyogenesis

J Hao, DB Sawyer, AK Hatzopoulos… - Recent patents on …, 2011 - ingentaconnect.com
Pluripotent stem cells, such as embryonic stem (ES) cells and induced pluripotent stem (iPS)
cells, hold great promise as a cell source for regenerative therapies to treat many major …