The blood–brain barrier (BBB) is a tightly regulated interface in the Central Nervous System
(CNS) that regulates the exchange of molecules in and out from the brain thus maintaining …

The critical role of the vasculature and its repair in neurological disease states is beginning
to emerge particularly for stroke, dementia, epilepsy, Parkinson's disease, tumors and …

In the adult brain, multiple cell types are known to produce factors that regulate blood–brain
barrier (BBB) properties, including astrocytes. Yet several recent studies disputed a role for …

Fibroblast growth factors (FGFs) act as key signalling molecules in brain development,
maintenance, and repair. They influence the intricate relationship between myelinating cells …

Astrocytes, which are homeostatic cells of the central nervous system (CNS), display
remarkable heterogeneity in their morphology and function. Besides their physical and …

The role of astrocytes in dysregulation of blood-brain barrier (BBB) function following
ischemic stroke is not well understood. Here, we investigate the effects of restoring the repair …

Stroke is a devastating medical condition, killing millions of people each year and causing
serious injury to many more. Despite advances in treatment, there is still little that can be …

Many traumatic brain injury (TBI) survivors sustain neurological disability and cognitive
impairments due to the lack of defined therapies to reduce TBI-induced blood-brain barrier …

Objective Cortical spreading depolarizations (CSDs) are intense and ubiquitous
depolarization waves relevant for the pathophysiology of migraine and brain injury. CSDs …

Previous studies have established the subventricular (SVZ) and subgranular (SGZ) zones as
sites of neurogenesis in the adult forebrain (Doetsch et al., 1999a; Doetsch, 2003a). Work …