The inositol 1, 4, 5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release
channels localized predominately in the endoplasmic reticulum of all cell types. They …

Intercellular calcium (Ca2+) waves (ICWs) represent the propagation of increases in
intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism …

Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune
bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the …

The endoplasmic reticulum (ER) is the largest single intracellular organelle, which is present
in all types of nerve cells. The ER is an interconnected, internally continuous system of …

Homologues of Drosophila Trp (transient receptor potential) form plasma membrane
channels that mediate Ca 2+ entry following the activation of phospholipase C by cell …

Changes in the intracellular concentration of calcium ions in neurons are involved in neurite
growth, development, and remodeling, regulation of neuronal excitability, increases and …

The inspiration for lipid bilayer research, without question, comes from the biological world.
Although self-assembled bilayer lipid membranes (BLMs) in vitro, were first reported in …

The Ca2+ coupling between endoplasmic reticulum (ER) and mitochondria is central to
multiple cell survival and cell death mechanisms. Cytoplasmic [Ca2+]([Ca2+] c) spikes and …

We report here the first three‐dimensional structure of the type 1 inositol 1, 4, 5‐
trisphosphate receptor (IP 3 R). From cryo‐electron microscopic images of purified receptors …

In many cell types the intracellular Ca2+ store performs a central role in the regulation of the
cytosolic Ca2+ concentration ([Ca2+] c), the elevation of which triggers diverse and …