Cancer cell states: Lessons from ten years of single-cell RNA-sequencing of human tumors
Human tumors are intricate ecosystems composed of diverse genetic clones and malignant
cell states that evolve in a complex tumor micro-environment. Single-cell RNA-sequencing …
cell states that evolve in a complex tumor micro-environment. Single-cell RNA-sequencing …
IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer
N Caronni, F La Terza, FM Vittoria, G Barbiera… - Nature, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with high resistance to
therapies. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …
therapies. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …
The resurgence of the Adora2b receptor as an immunotherapeutic target in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense desmoplastic
stroma that impedes drug delivery, reduces parenchymal blood flow, and suppresses the …
stroma that impedes drug delivery, reduces parenchymal blood flow, and suppresses the …
The hallmarks of precancer
Research on precancers, as defined as at-risk tissues and early lesions, is of high
significance given the effectiveness of early intervention. We discuss the need for risk …
significance given the effectiveness of early intervention. We discuss the need for risk …
Pancreatic Epithelial IL17/IL17RA Signaling Drives B7-H4 Expression to Promote Tumorigenesis
S Castro-Pando, RM Howell, L Li… - Cancer Immunology …, 2024 - aacrjournals.org
IL17 is required for the initiation and progression of pancreatic cancer, particularly in the
context of inflammation, as previously shown by genetic and pharmacological approaches …
context of inflammation, as previously shown by genetic and pharmacological approaches …
Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer
F De Sanctis, S Dusi, S Caligola, C Anselmi, V Petrova… - Immunity, 2024 - cell.com
Tumors weakly infiltrated by T lymphocytes poorly respond to immunotherapy. We aimed to
unveil malignancy-associated programs regulating T cell entrance, arrest, and activation in …
unveil malignancy-associated programs regulating T cell entrance, arrest, and activation in …
Spatial transcriptomic analysis of primary and metastatic pancreatic cancers highlights tumor microenvironmental heterogeneity
Although the spatial, cellular and molecular landscapes of resected pancreatic ductal
adenocarcinoma (PDAC) are well documented, the characteristics of its metastatic ecology …
adenocarcinoma (PDAC) are well documented, the characteristics of its metastatic ecology …
Spatial transcriptomic analysis drives PET imaging of tight junction protein expression in pancreatic cancer theranostics
Molecular imaging using positron emission tomography (PET) provides sensitive detection
and mapping of molecular targets. While cancer-associated fibroblasts and integrins have …
and mapping of molecular targets. While cancer-associated fibroblasts and integrins have …
PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration
ATF Bell, JT Mitchell, AL Kiemen, M Lyman, K Fujikura… - Cell Systems, 2024 - cell.com
This study introduces a new imaging, spatial transcriptomics (ST), and single-cell RNA-
sequencing integration pipeline to characterize neoplastic cell state transitions during …
sequencing integration pipeline to characterize neoplastic cell state transitions during …
From precursor to cancer: decoding the intrinsic and extrinsic pathways of pancreatic intraepithelial neoplasia progression
This review explores the progression of pancreatic intraepithelial neoplasia (PanIN) to
pancreatic ductal adenocarcinoma through a dual lens of intrinsic molecular alterations and …
pancreatic ductal adenocarcinoma through a dual lens of intrinsic molecular alterations and …