The blood-brain barrier (BBB) is formed by the endothelial cells of cerebral microvessels,
providing a dynamic interface between the peripheral circulation and the central nervous …

Restorative cell-based and pharmacological therapies for experimental stroke substantially
improve functional outcome. These therapies target several types of parenchymal cells …

Stroke is a leading cause of mortality and severe long-term disability worldwide.
Development of effective treatment or new therapeutic strategies for ischemic stroke patients …

Cerebral microvessels have a unique ultrastructure form, which allows for the close
relationship of the endothelium and blood elements to the neurons they serve, via …

Though the vascular system of the adult brain is extremely stable under normal baseline
conditions, endothelial cells start to proliferate in response to brain ischemia. The induction …

The adult mammalian brain contains a population of neural stem cells that can give rise to
neurons, astrocytes, and oligodendrocytes and are thought to be involved in certain forms of …

In an effort to elucidate the molecular mechanisms underlying cerebral vascular alteration
after stroke, the authors measured the spatial and temporal profiles of blood–brain barrier …

Angiogenesis is an intricately regulated phenomenon. Its mechanisms in the ischemic brain
have not been clearly elucidated. The authors investigated expression of angiogenesis …

In the present study, we show a biphasic activation of hypoxia inducible factor 1α (HIF-1)
after stroke that lasts for up to 10 d, suggesting the involvement of the HIF pathway in several …

Background—Vascular damage caused by cerebral ischemia leads to edema, hemorrhage
formation, and worsened outcomes in ischemic stroke patients. Therapeutic interventions …