Conventional therapy and promising plant-derived compounds against trypanosomatid parasites
Leishmaniasis and trypanosomiasis are two neglected and potentially lethal diseases that
affect mostly the poor and marginal populations of developing countries around the world …
affect mostly the poor and marginal populations of developing countries around the world …
Innovative lead compounds and formulation strategies as newer kinetoplastid therapies
The protozoan diseases leishmaniasis, human African trypanosomiasis (HAT) and Chagas
disease (CD) are responsible for substantial global morbidity and mortality in tropical and …
disease (CD) are responsible for substantial global morbidity and mortality in tropical and …
Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species
KZ Bernuci, CC Iwanaga, CMM Fernandez-Andrade… - Molecules, 2016 - mdpi.com
Essential oils from fresh Piperaceae leaves were obtained by hydrodistillation and analyzed
by gas chromatography mass spectrometry (GC–MS), and a total of 68 components were …
by gas chromatography mass spectrometry (GC–MS), and a total of 68 components were …
In Vitro Effects of the Neolignan 2,3‐Dihydrobenzofuran Against Leishmania Amazonensis
LG de Castro Oliveira, LM Brito… - Basic & Clinical …, 2017 - Wiley Online Library
Leishmaniasis is an infectious disease complex caused by protozoa from the Leishmania
genus, which presents a broad spectrum of clinical manifestations: cutaneous …
genus, which presents a broad spectrum of clinical manifestations: cutaneous …
[HTML][HTML] Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: Mitochondrion as a strategic target
D Lazarin-Bidóia, FP Garcia… - Memórias do Instituto …, 2022 - SciELO Brasil
Over the past years, natural products have been explored in order to find biological active
substances to treat various diseases. Regarding their potential action against parasites such …
substances to treat various diseases. Regarding their potential action against parasites such …
Relationship between environmental covariates and Ceylon tea cultivation in Sri Lanka
How the current distribution of tea cultivation is influenced by specific environmental
conditions in Sri Lanka is yet to be explored. Therefore, this study aims to assess the …
conditions in Sri Lanka is yet to be explored. Therefore, this study aims to assess the …
Trypanocidal action of (−)-elatol involves an oxidative stress triggered by mitochondria dysfunction
VC Desoti, D Lazarin-Bidóia, DB Sudatti, RC Pereira… - Marine Drugs, 2012 - mdpi.com
Natural compounds have shown good potential for the discovery of new chemotherapeutics
for the treatment of Chagas' disease. Recently, our group reported the effective trypanocidal …
for the treatment of Chagas' disease. Recently, our group reported the effective trypanocidal …
[HTML][HTML] Neolignan Licarin A presents effect against Leishmania (Leishmania) major associated with immunomodulation in vitro
PLN Néris, JPA Caldas, YKS Rodrigues… - Experimental …, 2013 - Elsevier
Leishmaniasis' treatment is based mostly on pentavalent antimonials or amphotericin B long-
term administration, expensive drugs associated with severe side effects. Considering these …
term administration, expensive drugs associated with severe side effects. Considering these …
Antiprotozoal activity of essential oils derived from Piper spp. grown in Colombia
SM Leal, N Pino, EE Stashenko… - Journal of Essential …, 2013 - Taylor & Francis
Plant species of the genus Piper are widely distributed throughout the Colombian territory.
Eleven Piper spp. essential oils (EO1–EO11) were chemically characterized and tested …
Eleven Piper spp. essential oils (EO1–EO11) were chemically characterized and tested …
[HTML][HTML] Further evidence of the trypanocidal action of eupomatenoid-5: confirmation of involvement of reactive oxygen species and mitochondria owing to a reduction …
D Lazarin-Bidóia, VC Desoti, T Ueda-Nakamura… - Free Radical Biology …, 2013 - Elsevier
Our group assays natural products that are less toxic and more effective than available
nitroheterocycles as promising therapeutic options for patients with Chagas disease. Our …
nitroheterocycles as promising therapeutic options for patients with Chagas disease. Our …