Conventional therapy and promising plant-derived compounds against trypanosomatid parasites

DS Alviano, ALS Barreto, FA Dias… - Frontiers in …, 2012 - frontiersin.org
Leishmaniasis and trypanosomiasis are two neglected and potentially lethal diseases that
affect mostly the poor and marginal populations of developing countries around the world …

Innovative lead compounds and formulation strategies as newer kinetoplastid therapies

S Espuelas, D Plano, P Nguewa, M Font… - Current medicinal …, 2012 - ingentaconnect.com
The protozoan diseases leishmaniasis, human African trypanosomiasis (HAT) and Chagas
disease (CD) are responsible for substantial global morbidity and mortality in tropical and …

Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species

KZ Bernuci, CC Iwanaga, CMM Fernandez-Andrade… - Molecules, 2016 - mdpi.com
Essential oils from fresh Piperaceae leaves were obtained by hydrodistillation and analyzed
by gas chromatography mass spectrometry (GC–MS), and a total of 68 components were …

In Vitro Effects of the Neolignan 2,3‐Dihydrobenzofuran Against Leishmania Amazonensis

LG de Castro Oliveira, LM Brito… - Basic & Clinical …, 2017 - Wiley Online Library
Leishmaniasis is an infectious disease complex caused by protozoa from the Leishmania
genus, which presents a broad spectrum of clinical manifestations: cutaneous …

[HTML][HTML] Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: Mitochondrion as a strategic target

D Lazarin-Bidóia, FP Garcia… - Memórias do Instituto …, 2022 - SciELO Brasil
Over the past years, natural products have been explored in order to find biological active
substances to treat various diseases. Regarding their potential action against parasites such …

Relationship between environmental covariates and Ceylon tea cultivation in Sri Lanka

SL Jayasinghe, L Kumar, MK Hasan - Agronomy, 2020 - mdpi.com
How the current distribution of tea cultivation is influenced by specific environmental
conditions in Sri Lanka is yet to be explored. Therefore, this study aims to assess the …

Trypanocidal action of (−)-elatol involves an oxidative stress triggered by mitochondria dysfunction

VC Desoti, D Lazarin-Bidóia, DB Sudatti, RC Pereira… - Marine Drugs, 2012 - mdpi.com
Natural compounds have shown good potential for the discovery of new chemotherapeutics
for the treatment of Chagas' disease. Recently, our group reported the effective trypanocidal …

[HTML][HTML] Neolignan Licarin A presents effect against Leishmania (Leishmania) major associated with immunomodulation in vitro

PLN Néris, JPA Caldas, YKS Rodrigues… - Experimental …, 2013 - Elsevier
Leishmaniasis' treatment is based mostly on pentavalent antimonials or amphotericin B long-
term administration, expensive drugs associated with severe side effects. Considering these …

Antiprotozoal activity of essential oils derived from Piper spp. grown in Colombia

SM Leal, N Pino, EE Stashenko… - Journal of Essential …, 2013 - Taylor & Francis
Plant species of the genus Piper are widely distributed throughout the Colombian territory.
Eleven Piper spp. essential oils (EO1–EO11) were chemically characterized and tested …

[HTML][HTML] Further evidence of the trypanocidal action of eupomatenoid-5: confirmation of involvement of reactive oxygen species and mitochondria owing to a reduction …

D Lazarin-Bidóia, VC Desoti, T Ueda-Nakamura… - Free Radical Biology …, 2013 - Elsevier
Our group assays natural products that are less toxic and more effective than available
nitroheterocycles as promising therapeutic options for patients with Chagas disease. Our …