Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer

M Hatakeyama - Proceedings of the Japan Academy, Series B, 2017 - jstage.jst.go.jp
Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor of
gastric cancer. The cagA gene-encoded CagA protein is delivered into gastric epithelial …

A dormant microbial component in the development of preeclampsia

DB Kell, LC Kenny - Frontiers in medicine, 2016 - frontiersin.org
Preeclampsia (PE) is a complex, multisystem disorder that remains a leading cause of
morbidity and mortality in pregnancy. Four main classes of dysregulation accompany PE …

Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA

A Shimoda, K Ueda, S Nishiumi, N Murata-Kamiya… - Scientific reports, 2016 - nature.com
CagA, encoded by cytotoxin-associated gene A (cagA), is a major virulence factor of
Helicobacter pylori, a gastric pathogen involved in the development of upper gastrointestinal …

Pre-Eclampsia: Microbiota possibly playing a role

E Ahmadian, YR Saadat, SMH Khatibi… - Pharmacological …, 2020 - Elsevier
Pre-eclampsia (PE) is a complication of pregnancy that is associated with mortality and
morbidity in mothers and fetuses worldwide. Oxygen dysregulation in the placenta …

Immunological tolerance, pregnancy, and preeclampsia: the roles of semen microbes and the father

LC Kenny, DB Kell - Frontiers in medicine, 2018 - frontiersin.org
Although it is widely considered, in many cases, to involve two separable stages (poor
placentation followed by oxidative stress/inflammation), the precise originating causes of …

[HTML][HTML] Individuality, phenotypic differentiation, dormancy and 'persistence'in culturable bacterial systems: commonalities shared by environmental, laboratory, and …

D Kell, M Potgieter, E Pretorius - F1000Research, 2015 - ncbi.nlm.nih.gov
For bacteria, replication mainly involves growth by binary fission. However, in a very great
many natural environments there are examples of phenotypically dormant, non-growing …

Meat and nicotinamide: A causal role in human evolution, history, and demographics

AC Williams, LJ Hill - International Journal of Tryptophan …, 2017 - journals.sagepub.com
Hunting for meat was a critical step in all animal and human evolution. A key brain-trophic
element in meat is vitamin B3/nicotinamide. The supply of meat and nicotinamide steadily …

Exposure to stimulatory CpG oligonucleotides during gestation induces maternal hypertension and excess vasoconstriction in pregnant rats

S Goulopoulou, CF Wenceslau… - American Journal …, 2016 - journals.physiology.org
Bacterial infections increase risk for pregnancy complications, such as preeclampsia and
preterm birth. Unmethylated CpG DNA sequences are present in bacterial DNA and have …

Helicobacter pylori and Chlamydia trachomatis in Sudanese women with preeclampsia

MA Ahmed, NG Hassan, ME Omer… - The Journal of …, 2020 - Taylor & Francis
Abstract Background: Helicobacter pylori and Chlamydia trachomatis infections are
associated with many complications of pregnancy including preeclampsia. The association …

Causal associations between Helicobacter pylori infection and pregnancy and neonatal outcomes: a two-sample Mendelian randomization study

J Huang, Y Liu, D Xu, M Chen, Q Xie, J Chen… - Frontiers in Cellular …, 2024 - frontiersin.org
Background Observational studies have reported that Helicobacter pylori (H. pylori) infection
is associated with a series of pregnancy and neonatal outcomes. However, the results have …