Mechanism of Candida pathogenesis: revisiting the vital drivers
Candida is the most implicated fungal pathogen in the clinical setting. Several factors play
important roles in the pathogenesis of Candida spp. Multiple transcriptional circuits …
important roles in the pathogenesis of Candida spp. Multiple transcriptional circuits …
Fungal cell wall proteins and signaling pathways form a cytoprotective network to combat stresses
C Ibe, CA Munro - Journal of Fungi, 2021 - mdpi.com
Candida species are part of the normal flora of humans, but once the immune system of the
host is impaired and they escape from commensal niches, they shift from commensal to …
host is impaired and they escape from commensal niches, they shift from commensal to …
The high osmolarity glycerol (HOG) pathway in fungi†
H Yaakoub, NS Sanchez, L Ongay-Larios… - Critical Reviews in …, 2022 - Taylor & Francis
While fungi are widely occupying nature, many species are responsible for devastating
mycosis in humans. Such niche diversity explains how quick fungal adaptation is necessary …
mycosis in humans. Such niche diversity explains how quick fungal adaptation is necessary …
High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis
The innate immune system is the first line of defense against invasive fungal infections. As a
consequence, many successful fungal pathogens have evolved elegant strategies to interact …
consequence, many successful fungal pathogens have evolved elegant strategies to interact …
Stress-activated protein kinases in human fungal pathogens
AM Day, J Quinn - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
The ability of fungal pathogens to survive hostile environments within the host depends on
rapid and robust stress responses. Stress-activated protein kinase (SAPK) pathways are …
rapid and robust stress responses. Stress-activated protein kinase (SAPK) pathways are …
Inhibition of Classical and Alternative Modes of Respiration in Candida albicans Leads to Cell Wall Remodeling and Increased Macrophage Recognition
The human fungal pathogen Candida albicans requires respiratory function for normal
growth, morphogenesis, and virulence. Mitochondria therefore represent an enticing target …
growth, morphogenesis, and virulence. Mitochondria therefore represent an enticing target …
Mitochondrial targeting of Candida albicans SPFH proteins and requirement of stomatins for SDS-induced stress tolerance
H Kim, MY Heredia, X Chen, M Ahmed… - Microbiology …, 2024 - journals.asm.org
The SPFH (stomatin, prohibitin, flotillin, and HflK/HflC) protein superfamily is conserved
across all domains of life. Fungal SPFH proteins are required for respiration, stress …
across all domains of life. Fungal SPFH proteins are required for respiration, stress …
The role of glycoside hydrolases in S. gordonii and C. albicans interactions
Candida albicans can coaggregate with Streptococcus gordonii and cocolonize in the oral
cavity. Saliva provides a vital microenvironment for close interactions of oral …
cavity. Saliva provides a vital microenvironment for close interactions of oral …
An expanded cell wall damage signaling network is comprised of the transcription factors Rlm1 and Sko1 in Candida albicans
MY Heredia, MAC Ikeh, D Gunasekaran… - PLoS …, 2020 - journals.plos.org
The human fungal pathogen Candida albicans is constantly exposed to environmental
challenges impacting the cell wall. Signaling pathways coordinate stress adaptation and are …
challenges impacting the cell wall. Signaling pathways coordinate stress adaptation and are …
Transcriptional regulation of the caspofungin-induced cell wall damage response in Candida albicans
The human fungal pathogen Candida albicans maintains pathogenic and commensal states
primarily through cell wall functions. The echinocandin antifungal drug caspofungin inhibits …
primarily through cell wall functions. The echinocandin antifungal drug caspofungin inhibits …