Few investigators think of bone as an endocrine gland, even after the discovery that
osteocytes produce circulating fibroblast growth factor 23 that targets the kidney and …

The capacity of bone tissue to alter its mass and structure in response to mechanical
demands has long been recognized but the cellular mechanisms involved remained poorly …

This second edition of the Bone Mechanics Handbook summarizes the current
understanding of bone mechanics with comprehensive coverage of the histology …

As a result of fatigue, bone sustains microdamage, which is then repaired by bone‐
remodeling processes. How osteoclastic activity is targeted at the removal of microdamaged …

Bone is an extremely complex tissue that provides many essential functions in the body.
Bone tissue engineering holds great promise in providing strategies that will result in …

Once osteoblasts have completed their bone‐forming function, they are either entrapped in
bone matrix and become osteocytes or remain on the surface as lining cells. Nonetheless …

Bone remodeling achieves three goals. First, it provides a way for the body to alter the
balance of essential minerals by increasing or decreasing the concentration of these in …

Chondrocyte hypertrophy is a mandatory step during endochondral ossification. Cbfa1-
deficient mice lack hypertrophic chondrocytes in some skeletal elements, indicating that …

Intracortical remodeling in the adult skeleton removes and replaces areas of compact bone
that have sustained microdamage. Although studies have been performed in animal species …

Bone is removed or replaced in defined locations by targeting osteoclasts and osteoblasts in
response to its local history of mechanical loading. There is increasing evidence that …