Deciding what to do and when to move is vital to our survival. Clinical and fundamental
studies have identified basal ganglia circuits as critical for this process. The main input …

Behavior is readily classified into patterns of movements with inferred common goals—
actions. Goals may be discrete; movements are continuous. Through the careful study of …

The cortex projects to the dorsal striatum topographically, to regulate behaviour,–, but
spiking activity in the two structures has previously been reported to have markedly different …

Hypotheses of striatal orchestration of behavior ascribe distinct functions to striatal
subregions, with the dorsolateral striatum (DLS) especially implicated in habitual and skilled …

The dorsal striatum (dS) has been implicated in storing procedural memories and controlling
movement kinematics. Since procedural memories are expressed through movements, the …

The ability to sequence movements in response to new task demands enables rich and
adaptive behavior. However, such flexibility is computationally costly and can result in …

The striatum is critical for controlling motor output. However, it remains unclear how striatal
output neurons encode and facilitate movement. A prominent theory suggests that striatal …

The dorsal striatum plays a central role in the selection, execution, and evaluation of actions.
An emerging model attributes action selection to the matrix and evaluation to the striosome …

Our brain can be recognized as a network of largely hierarchically organized neural circuits
that operate to control specific functions, but when acting in parallel, enable the performance …

Animals must slow or halt locomotion to integrate sensory inputs or to change direction. In
Caenorhabditis elegans, the GABAergic and peptidergic neuron RIS mediates …