In eukaryotic cells, protein and RNA factors involved in genome activities like transcription,
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …

Intrinsically disordered regions (IDRs) are especially enriched among proteins that regulate
chromatin and transcription. As a result, mechanisms that influence specificity of IDR-driven …

Chromatin, which consists of DNA and associated proteins, contains genetic information and
is a mechanical component of the nucleus. Heterochromatic histone methylation controls …

In eukaryotic cells, structures called heterochromatin play critical roles in nuclear processes
ranging from gene repression to chromosome segregation. Biochemical and in vivo studies …

Antiandrogen strategies remain the prostate cancer treatment backbone, but drug resistance
develops. We show that androgen blockade in prostate cancer leads to derepression of …

Three decades of research have established the CCCTC-binding factor (CTCF) as a
ubiquitously expressed chromatin organizing factor and master regulator of gene …

Gene silencing is intimately connected to DNA condensation and the formation of
transcriptionally inactive heterochromatin by Heterochromatin Protein 1α (HP1α). Because …

EGFR inhibitors (EGFRi) are standard-of-care treatments administered to patients with non–
small cell lung cancer (NSCLC) that harbor EGFR alterations. However, development of …

Isoforms of heterochromatin protein 1 (HP1) have been known to perform a multitude of
functions ranging from gene silencing, gene activation to cell cycle regulation, and cell …

Despite advances in the identification of chromatin regulators and genome interactions, the
principles of higher‐order chromatin structure have remained elusive. Here, we applied …