Coronavirus membrane fusion mechanism offers a potential target for antiviral development
Abstract The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the
need to develop effective therapies against the causative agent, SARS-CoV-2, and also …
need to develop effective therapies against the causative agent, SARS-CoV-2, and also …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection
The recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is
responsible for a worldwide pandemic. Given the global health emergency, drug …
responsible for a worldwide pandemic. Given the global health emergency, drug …
Structural dynamics of SARS-CoV-2 variants: A health monitoring strategy for anticipating Covid-19 outbreaks
Objectives the Covid-19 pandemic has been marked by sudden outbreaks of SARS-CoV-2
variants harboring mutations in both the N-terminal (NTD) and receptor binding (RBD) …
variants harboring mutations in both the N-terminal (NTD) and receptor binding (RBD) …
Synergistic antiviral effect of hydroxychloroquine and azithromycin in combination against SARS-CoV-2: What molecular dynamics studies of virus-host interactions …
The emergence of SARS-coronavirus-2 (SARS-CoV-2) has led to a global pandemic
disease referred to as coronavirus disease 19 (COVID-19). Hydroxychloroquine (CLQ …
disease referred to as coronavirus disease 19 (COVID-19). Hydroxychloroquine (CLQ …
[HTML][HTML] Virus entry: molecular mechanisms and biomedical applications
DS Dimitrov - Nature Reviews Microbiology, 2004 - nature.com
Viruses have evolved to enter cells from all three domains of life—Bacteria, Archaea and
Eukaryotes. Of more than 3,600 known viruses, hundreds can infect human cells and most of …
Eukaryotes. Of more than 3,600 known viruses, hundreds can infect human cells and most of …
[HTML][HTML] The role of glycosphingolipids in immune cell functions
Glycosphingolipids (GSLs) exhibit a variety of functions in cellular differentiation and
interaction. Also, they are known to play a role as receptors in pathogen invasion. A less well …
interaction. Also, they are known to play a role as receptors in pathogen invasion. A less well …
Pathogens: raft hijackers
Throughout evolution, organisms have developed immune-surveillance networks to protect
themselves from potential pathogens. At the cellular level, the signalling events that regulate …
themselves from potential pathogens. At the cellular level, the signalling events that regulate …
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation
M Mellado, JM Rodríguez-Frade… - Annual review of …, 2001 - annualreviews.org
A broad array of biological responses, including cell polarization, movement, immune and
inflammatory responses, and prevention of HIV-1 infection, are triggered by the chemokines …
inflammatory responses, and prevention of HIV-1 infection, are triggered by the chemokines …
Lipid rafts and HIV pathogenesis: host membrane cholesterol is required for infection by HIV type 1
Z Liao, LM Cimakasky, R Hampton, DH Nguyen… - Journal of …, 2004 - liebertpub.com
In a previous study we showed that budding of HIV-1 particles occurs at highly specialized
membrane microdomains known as lipid rafts. These microdomains are characterized by a …
membrane microdomains known as lipid rafts. These microdomains are characterized by a …