Targeting tumor-associated macrophages for cancer treatment
M Li, L He, J Zhu, P Zhang, S Liang - Cell & bioscience, 2022 - Springer
Tumor-associated macrophages (TAMs) are abundant, nearly accounting for 30–50% of
stromal cells in the tumor microenvironment. TAMs exhibit an immunosuppressive M2-like …
stromal cells in the tumor microenvironment. TAMs exhibit an immunosuppressive M2-like …
[HTML][HTML] Recent advances in long-acting drug delivery systems for anticancer drug
The use of systemic anticancer chemotherapy is intrinsically limited by its toxicity. Whether
dealing with small molecules or biopharmaceuticals, after systemic administration, small …
dealing with small molecules or biopharmaceuticals, after systemic administration, small …
Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy
Glioblastoma multiforme (GBM) remains incurable despite aggressive implementation of
multimodal treatments after surgical debulking. Almost all patients with GBM relapse within a …
multimodal treatments after surgical debulking. Almost all patients with GBM relapse within a …
Single-dose injectable nanovaccine-in-hydrogel for robust immunotherapy of large tumors with abscopal effect
Current cancer immunotherapy [eg, immune checkpoint blockade (ICB)] only benefits small
subsets of patients, largely due to immunosuppressive tumor microenvironment (TME). In …
subsets of patients, largely due to immunosuppressive tumor microenvironment (TME). In …
Chemically engineering cells for precision medicine
Y Wang, Z Li, F Mo, TJ Chen-Mayfield, A Saini… - Chemical Society …, 2023 - pubs.rsc.org
Cell-based therapy holds great potential to address unmet medical needs and revolutionize
the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell …
the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell …
[HTML][HTML] Cancer nanomedicine in preoperative therapeutics: Nanotechnology-enabled neoadjuvant chemotherapy, radiotherapy, immunotherapy, and phototherapy
Surgical resection remains a mainstay in the treatment of malignant solid tumors. However,
the use of neoadjuvant treatments, including chemotherapy, radiotherapy, phototherapy …
the use of neoadjuvant treatments, including chemotherapy, radiotherapy, phototherapy …
Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation
Cancer radio-immunotherapy, integrating external/internal radiation therapy with immuno-
oncology treatments, emerges in the current management of cancer. A growing number of …
oncology treatments, emerges in the current management of cancer. A growing number of …
Enhancing in situ cancer vaccines using delivery technologies
In situ cancer vaccination refers to any approach that exploits tumour antigens available at a
tumour site to induce tumour-specific adaptive immune responses. These approaches hold …
tumour site to induce tumour-specific adaptive immune responses. These approaches hold …
A general biomineralization strategy to synthesize autologous cancer vaccines with cGAS-STING activating capacity for postsurgical immunotherapy
Autologous cancer vaccines constructed by nonproliferative whole tumor cells or tumor
lysates together with appropriate adjuvants represent a promising strategy to suppress …
lysates together with appropriate adjuvants represent a promising strategy to suppress …
Extracellular matrix viscosity reprogramming by in situ Au bioreactor-boosted microwavegenetics disables tumor escape in CAR-T immunotherapy
D Wang, M Zhang, G Qiu, C Rong, X Zhu, G Qin… - ACS …, 2023 - ACS Publications
Incomplete microwave ablation (iMWA) caused by uncontrollable heat diffusion enhances
the immunosuppressive tumor microenvironment (ITM), consequently disabling the …
the immunosuppressive tumor microenvironment (ITM), consequently disabling the …