Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA
to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs. ACC1 …

Having direct access to brain vasculature, astrocytes can take up available blood nutrients
and metabolize them to fulfil their own energy needs and deliver metabolic intermediates to …

Background Many metabolites serve as important signalling molecules to adjust cellular
activities and functions based on nutrient availability. Links between acetyl-CoA metabolism …

Mycolic acids are major and specific lipid components of the mycobacterial cell envelope
and are essential for the survival of members of the genus Mycobacterium that contains the …

Studies of genetic adaptation, a central focus of evolutionary biology, most often focus on the
host's genome and only rarely on its co-evolved microbiome. The Qinghai-Tibetan Plateau …

Nowadays the global tendency towards physical activity reduction and an augmented
dietary intake of fats, sugars and calories is leading to a growing propagation of overweight …

A distinctive feature of cancer cells of various origins involves alterations of the composition
of lipids, with significant enrichment in monounsaturated fatty acids. These molecules, in …

There is a renewed interest in the ultimate role of fatty acid synthase (FASN)—a key
lipogenic enzyme catalysing the terminal steps in the de novo biogenesis of fatty acids—in …

Simultaneous inhibition of the acetyl-CoA carboxylase (ACC) isozymes ACC1 and ACC2
results in concomitant inhibition of fatty acid synthesis and stimulation of fatty acid oxidation …