▪ Abstract Expressed protein ligation (EPL) is a protein engineering approach that allows
recombinant and synthetic polypeptides to be chemoselectively and regioselectively joined …

The matrix metalloproteinases (MMP)-2 and-9, also known as the gelatinases have been
long recognized as major contributors to the proteolytic degradation of extracellular matrix …

Several macrocyclic peptides (∼ 30 amino acids), with diverse biological activities, have
been isolated from the Rubiaceae and Violaceae plant families over recent years. We have …

Combinatorial libraries of synthetic and natural products are an important source of
molecular information for the interrogation of biological targets. Methods for the intracellular …

▪ Abstract Protein splicing is a form of posttranslational processing that consists of the
excision of an intervening polypeptide sequence, the intein, from a protein, accompanied by …

The proteasome plays a central role in the degradation of regulatory and misfolded proteins.
Current models suggest that substrates access the internal catalytic sites by processively …

Biophysical techniques such as fluorescence spectroscopy and nuclear magnetic
resonance (NMR) spectroscopy provide a window into the inner workings of proteins. These …

This manuscript is part of a debate on the statement that “the use of short synthetic adhesion
peptides, like RGD, is the best approach in the design of biomaterials that guide cell …

Kinetically controlled ligation for the convergent chemical synthesis of proteins. - Abstract -
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Protein splicing, the protein equivalent of RNA splicing, is a newly discovered
posttranslational process that proceeds through a branched protein intermediate and …