Ferroportin Disease (FD) is an autosomal dominant hereditary iron loading disorder
associated with heterozygote mutations of the ferroportin-1 (FPN) gene. It represents one of …

The discovery of hepcidin in 2000 and the subsequent unprecedented explosion of research
and discoveries in the iron field have dramatically changed our understanding of human …

Src‐homology 2 domain–containing phosphatase 2 (Shp2) has been reported to play an
important role in the maintenance and self‐renewal of embryonic and adult stem cells, but its …

Although progress in imaging and genetics allow for a noninvasive diagnosis of most cases
of genetic iron overload, liver pathology remains often useful (1) to assess prognosis by …

This review acknowledges the recent and dramatic advancement in the field of
hemochromatosis and highlights the surprising analogies with a prototypic endocrine …

Background Reference standard indices of iron deficiency and iron overload are generally
invasive, expensive, and can be unpleasant or occasionally risky. Ferritin is an iron storage …

Dysmetabolic iron overload syndrome (DIOS) corresponds to mild increase in both liver and
body iron stores associated with various components of metabolic syndrome in the absence …

Hepatitis B virus (HBV) reactivation in hepatitis B surface antigen (HBsAg)–negative,
antibody to hepatitis B core antigen (anti‐HBc)–positive patients after allogeneic …

Iron overload diseases of genetic origin are an ever changing world, due to major advances
in genetics and molecular biology. Five major categories are now established: HFE-related …

BACKGROUND & AIMS: Classical ferroportin disease is characterized by hyperferritinemia,
normal transferrin saturation, and iron overload in macrophages. A non-classical form is …