The high morbidity and mortality of non-small cell lung cancer (NSCLC) have always been
major threats to people's health. With the identification of carcinogenic drivers in non-small …

Nanomedicine application in cancer therapy is an urgency because of inability of current
biological therapies for complete removal of tumor cells. The development of smart and …

Lung squamous cell carcinoma (LUSC) is associated with high mortality and has few
therapeutic options. Chemotherapy remains the main treatment for LUSC patients, but multi …

The loss of E-cadherin, an epithelial cell adhesion molecule, has been implicated in
metastasis by mediating the epithelial–mesenchymal transition, which promotes invasion …

Human endogenous retroviruses (HERVs) are remnants of ancient retroviral infections in the
host genome. Although mutations and silencing mechanisms impair their original role in …

Abstract Background DNA methyltransferase 3A (DNMT3A) is frequently mutated in acute
myeloid leukemia (AML) with Arg882His (R882H) as the hotspot mutation. It has been …

Transposable elements (TEs), comprising nearly 50% of the human genome, have
transitioned from being perceived as “genomic junk” to key players in cancer progression …

The loss of E-cadherin (E-cad), an epithelial cell adhesion molecule, has been implicated in
the epithelial-mesenchymal transition (EMT), promoting invasion and migration of cancer …

Background: Oncogenic PIK3CA mutations (PIK3CAmut) frequently occur in a higher
proportion in luminal breast cancer (LBC), especially in refractory advanced cases, and are …

Cancer is one of the leading causes of death worldwide, and more effective ways of
attacking cancer are being sought. Cancer immunotherapy is a new and effective …