Ferrocene is an important structural core in bioorganometallic chemistry because of its
inherent stability, excellent redox properties, and low toxicity. Ferroquine and ferrocifen are …

Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death
worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases …

As a result of the biological activities of natural flavonoids, several synthetic strategies
aiming to obtain analogues with improved potency and/or pharmacokinetic profile have …

In the present investigation, the parent compound 4-amino-5-(4-fluoro-3-phenoxyphenyl)-4
H-1, 2, 4-triazole-3-thiol (1) and its Schiff bases 2, 3, and 4 were subjected to whole-cell anti …

Background: Polypharmacology means drugs having interactions with multiple targets of a
unique disease or many disease pathways. This concept has been greatly appreciated …

Background: Inhibition of human carbonic anhydrase (hCA) isoforms IX and XII with
concurrent inhibition of cathepsin B is a promising approach for targeting cancers …

Tuberculosis regimens currently applied in clinical practice require months of multidrug
therapy, which imposes a major challenge of patient compliance and drug resistance …

Microwave promoted high yielding synthesis of 4-aminoquinoline-phthalimides was
developed with an aim to evaluate their anti-plasmodial potential. The scaffolds with longer …

After the pandemic COVID-19, global health agencies remind us that tuberculosis is the
deadliest infectious disease worldwide. As per WHO reports, approximately ten million …

Aiming toward compounds with improved anti-Toxoplasma activity by exploiting the parasite
auxotrophies, a library of nucleobase-tethered trithiolato-bridged dinuclear ruthenium (II) …