Programmed death protein 1 (PD1) is a common immunosuppressive member on the
surface of T cells and plays an imperative part in downregulating the immune system and …

Osteosarcoma (OS) is the most common primary malignancy of the bone and has a high
propensity for local invasion and metastasis. Although combining surgery with …

Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children,
adolescents, and young adults, and with a second peak of incidence in elderly individuals …

Several cancers are highly refractory to conventional chemotherapy. The survival of tumors
in several cases is assisted by checkpoint immunomodulation to maintain the imbalance …

Introduction: Current treatment of osteosarcoma includes surgical resection of all gross
disease in conjunction with systemic chemotherapy to control micro-metastatic disease. This …

Osteosarcoma is the most common primary bone malignancy in adolescents. Its high
propensity to metastasize is the leading cause for treatment failure and poor prognosis …

Osteosarcomas (OSs) are bone tumors most commonly found in pediatric and adolescent
patients characterized by high risk of metastatic progression and recurrence after therapy …

Importance There is a strong rationale for treating sarcomas with immunotherapy. Objective
To assess the efficacy and safety of programmed cell death protein 1 (PD-1) targeting in …

Osteosarcoma is the most common primary malignant bone tumor and is associated with a
high risk of recurrence and distant metastasis. Effective treatment for osteosarcoma …

Signal transducer and activator of transcription 3 (STAT3) is one of seven STAT family
members involved with the regulation of cellular growth, differentiation and survival. STAT …