Homeostatic control of plasma K+ is a necessary physiological function. The daily dietary K+
intake of~ 100 mmol is excreted predominantly by the distal tubules of the kidney. About …

Molecular cloning experiments have identified the existence of two H+-K+-ATPases (HKAs),
colonic and gastric. Recent functional and molecular studies indicate the presence of both …

Previous studies using isolated tissues suggest that the colonic H, K-ATPase (cHKA),
expressed in the colon and kidney, plays an important role in K+ conservation. To test the …

Short-chain fatty acid (SCFA) transport across the colon may occur by nonionic diffusion
and/or via apical membrane SCFA−/HCO 3− exchange. To examine the relative importance …

The colon has large capacities for K+ absorption and K+ secretion, but its role in maintaining
K+ homeostasis is often overlooked. For many years, passive diffusion and/or solvent drag …

The functional properties and the pharmacological profile of the recently cloned cDNA
colonic P-ATPase α subunit (Crowson, MS, and Shull, GE (1992) J. Biol. Chem. 267, 13740 …

Pancreas secretes fluid rich in digestive enzymes and bicarbonate. The alkaline secretion is
important in buffering of acid chyme entering duodenum and for activation of enzymes. This …

HK-ATPase type 2 (HKA2), also known as the “nongastric” or “colonic” HK-ATPase, is
broadly expressed, and its presence in the kidney has puzzled experts in the field of renal …

Active K absorption in the rat distal colon is energized by an apical membrane HK-ATPase,
whereas K absorption in the distal collecting duct is generally believed to be modulated by a …

The Na-K/HK-ATPase gene family is divided in three subgroups including the Na-K-
ATPases, mainly involved in whole body and cellular ion homeostasis, the gastric HK …