Zinc complexes with nitrogen donor ligands as anticancer agents

M Porchia, M Pellei, F Del Bello, C Santini - Molecules, 2020 - mdpi.com
The search for anticancer metal-based drugs alternative to platinum derivatives could not
exclude zinc derivatives due to the importance of this metal for the correct functioning of the …

Metal complexes of NSAIDs as potent anti-tumor chemotherapeutics: Mechanistic insights into cytotoxic activity via multiple pathways primarily by inhibition of COX–1 …

HY Khan, S Parveen, I Yousuf, S Tabassum… - Coordination Chemistry …, 2022 - Elsevier
Non–steroidal anti-inflammatory drugs (NSAIDs) have gained considerable attention due to
their well–established medicinal properties such as anti-inflammatory, anti-bacterial, anti …

Multispecific Platinum (IV) Complex Deters Breast Cancer via Interposing Inflammation and Immunosuppression as an Inhibitor of COX‐2 and PD‐L1

S Jin, N Muhammad, Y Sun, Y Tan, H Yuan… - Angewandte …, 2020 - Wiley Online Library
Breast cancer (BC) is one of the most common malignancies in women and often
accompanied by inflammatory processes. Cyclooxygenase‐2 (COX‐2) plays a vital role in …

New apoptosis inducers containing anti-inflammatory drugs and pnictogen derivatives: a new strategy in the development of mitochondrial targeting …

CN Banti, C Papatriantafyllopoulou… - Journal of Medicinal …, 2023 - ACS Publications
{[Ag8 (Mef) 8 (μ2-S, O-DMSO) 2 (μ2-O-DMSO) 2 (O-DMSO) 8]· 2 (H2O)}(1),[Ag (Mef)(tpP)
2](2),[Ag (Mef)(tpAs) 3](3), and {2 [Ag (Mef)(tpSb) 3](DMSO)}(4) were obtained by the …

Evaluation of toxicity with brine shrimp assay

CN Banti, SK Hadjikakou - Bio-protocol, 2021 - bio-protocol.org
The in vivo toxicity of new metallodrugs either as Small Bioactive Molecules (SBAMs) or
Conjugates of Metals with Drugs (CoMeDs) or their hydrogels such as with hydroxyethyl …

Mechanistic studies of in vitro anti-proliferative and anti-inflammatory activities of the Zn (ii)–NSAID complexes of 1, 10-phenanthroline-5, 6-dione in MDA-MB-231 …

J Deb, TR Lakshman, I Ghosh, SS Jana… - Dalton Transactions, 2020 - pubs.rsc.org
Two zinc (II)–NSAID complexes [(phendione) ZnII (NPR) 2 (H2O) 2](1) and [(phendione) ZnII
(MFN) 2](2)(HNPR= naproxen and HMFN= mefenamic acid) of 1, 10-phenanthroline-5, 6 …

The aryl hydrocarbon receptor (AhR) as a breast cancer drug target

JR Baker, JA Sakoff… - Medicinal research reviews, 2020 - Wiley Online Library
Breast cancer is the most common cancer in women, with more than 1.7 million diagnoses
worldwide per annum. Metastatic breast cancer remains incurable, and the presence of …

Non-Steroidal Anti-Inflammatory Drugs Loaded to Micelles for the Modulation of Their Water Solubility

CN Banti, AG Kalampounias… - International Journal of …, 2023 - mdpi.com
The low water solubility of aspirin (ASPH) is well known, creating research challenges
regarding both its composition and its delivery. Therefore, the development of new aspirin …

Mitochondriotropic agents conjugated with NSAIDs through metal ions against breast cancer cells

CN Banti, AA Piperoudi, CP Raptopoulou… - Journal of Inorganic …, 2024 - Elsevier
Two copper (I) polymorphs of formula [Cu (SALH)(TPP) 3](1a and 1b) were prepared by the
conjugation of the Non-Steroidal Anti-Inflammatory Drug (NSAID) salicylic acid (SALH 2) …

Non steroidal anti-inflammatory drug (NSAIDs) in breast cancer chemotherapy; antimony (V) salicylate a DNA binder

NM Polychronis, CN Banti, CP Raptopoulou… - Inorganica Chimica …, 2019 - Elsevier
The organoantimony (V) derivative of salicylic acid (SalH 2),{[Ph 3 Sb (SalH)] 2 O}(SalOSbi)
was synthesized and tested for its anti-proliferative activity. SalOSbi was characterized by …