Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …

Targeted protein degradation (TPD) technology is based on a unique pharmacological
mechanism that has profoundly revolutionized medicinal research by overcoming limitations …

The circadian system is an intricate molecular network of coordinating circadian clocks that
organize the internal synchrony of the organism in response to the environment. These …

In addition to its profound implications in the fight against cancer, pyroptosis have important
role in the regulation of neuronal injury. Microglia are not only central members of the …

Homeodomain-interacting protein kinases (HIPKs) belong to the CMGC kinase family and
are closely related to dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) …

Huntington's disease (HD) is a monogenetic neurodegenerative disease, which serves as a
model of neurodegeneration with protein aggregation. Autophagy has been suggested to …

The percentage of elderly people in the world is increasing at an unprecedented pace; so it
is in China, which has the world's largest population and a high ratio of the seniors (aged 60 …

Abstract See Huang and Gitler (doi: 10.1093/brain/awy112) for a scientific commentary on
this article. Lowering the levels of disease-causing proteins is an attractive treatment …

Huntington's disease is a rare neurodegenerative disease caused by a cytosine–adenine–
guanine (CAG) trinucleotide expansion in the Huntingtin (HTT) gene. Although Huntington's …

The immediate early gene Arc is a master regulator of synaptic function and a critical
determinant of memory consolidation. Here, we show that Arc interacts with dynamic …