Macrophages in health and disease

MD Park, A Silvin, F Ginhoux, M Merad - Cell, 2022 - cell.com
The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

STAT proteins in cancer: orchestration of metabolism

YJ Li, C Zhang, A Martincuks, A Herrmann… - Nature reviews Cancer, 2023 - nature.com
Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease–novel insights into cellular communication circuits

M Peiseler, R Schwabe, J Hampe, P Kubes… - Journal of …, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …

Immune cell-mediated features of non-alcoholic steatohepatitis

T Huby, EL Gautier - Nature reviews immunology, 2022 - nature.com
Non-alcoholic fatty liver disease (NAFLD) includes a range of hepatic manifestations,
starting with liver steatosis and potentially evolving towards non-alcoholic steatohepatitis …

Mechanisms and disease consequences of nonalcoholic fatty liver disease

R Loomba, SL Friedman, GI Shulman - Cell, 2021 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

The immunological and metabolic landscape in primary and metastatic liver cancer

X Li, P Ramadori, D Pfister, M Seehawer… - Nature Reviews …, 2021 - nature.com
The liver is the sixth most common site of primary cancer in humans, and generally arises in
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …

[HTML][HTML] Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma

D Du, C Liu, M Qin, X Zhang, T Xi, S Yuan… - … Pharmaceutica Sinica B, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is an aggressive human cancer with increasing incidence
worldwide. Multiple efforts have been made to explore pharmaceutical therapies to treat …

Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

A researcher's guide to preclinical mouse NASH models

S Gallage, JEB Avila, P Ramadori, E Focaccia… - Nature …, 2022 - nature.com
Non-alcoholic fatty liver disease (NAFLD) and its inflammatory form, non-alcoholic
steatohepatitis (NASH), have quickly risen to become the most prevalent chronic liver …

[HTML][HTML] Excess body weight: Novel insights into its roles in obesity comorbidities

X Zhang, S Ha, HCH Lau, J Yu - Seminars in cancer biology, 2023 - Elsevier
Excess body weight is a global health problem due to sedentary lifestyle and unhealthy diet,
affecting 2 billion population worldwide. Obesity is a major risk factor for metabolic diseases …