Tissue tregs
M Panduro, C Benoist, D Mathis - Annual review of immunology, 2016 - annualreviews.org
The immune system is responsible for defending an organism against the myriad of
microbial invaders it constantly confronts. It has become increasingly clear that the immune …
microbial invaders it constantly confronts. It has become increasingly clear that the immune …
[HTML][HTML] De novo lipogenesis in metabolic homeostasis: More friend than foe?
Background An acute surplus of carbohydrates, and other substrates, can be converted and
safely stored as lipids in adipocytes via de novo lipogenesis (DNL). However, in obesity, a …
safely stored as lipids in adipocytes via de novo lipogenesis (DNL). However, in obesity, a …
[PDF][PDF] Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity
The visceral adipose tissue (VAT) of lean mice hosts a unique population of regulatory T
cells (Tregs) that have a distinct transcriptome and T cell receptor (TCR) repertoire and …
cells (Tregs) that have a distinct transcriptome and T cell receptor (TCR) repertoire and …
Suppression by TFR cells leads to durable and selective inhibition of B cell effector function
Follicular regulatory T cells (TFR cells) inhibit follicular helper T cell (TFH cell)–mediated
antibody production. The mechanisms by which TFR cells exert their key immunoregulatory …
antibody production. The mechanisms by which TFR cells exert their key immunoregulatory …
[HTML][HTML] Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis
DE Gaddis, LE Padgett, R Wu, C McSkimming… - Nature …, 2018 - nature.com
Regulatory T (Treg) cells contribute to the anti-inflammatory response during atherogenesis.
Here we show that during atherogenesis Treg cells lose Foxp3 expression and their …
Here we show that during atherogenesis Treg cells lose Foxp3 expression and their …
[HTML][HTML] T cells in adipose tissue: critical players in immunometabolism
Q Wang, H Wu - Frontiers in immunology, 2018 - frontiersin.org
Adipose tissue performs immunoregulatory functions in addition to fat storage. Various T
cells in different fat depots either help maintain metabolic homeostasis under healthy …
cells in different fat depots either help maintain metabolic homeostasis under healthy …
[PDF][PDF] The cellular and molecular basis of translational immunometabolism
The immune response requires major changes to metabolic processes, and indeed, energy
metabolism and functional activation are fully integrated in immune cells to determine their …
metabolism and functional activation are fully integrated in immune cells to determine their …
Inflammation and macrophage modulation in adipose tissues
VJ Vieira‐Potter - Cellular microbiology, 2014 - Wiley Online Library
The adipose tissue is an active endocrine organ that harbours not only mature and
developing adipocytes but also a wide array of immune cells, including macrophages, a key …
developing adipocytes but also a wide array of immune cells, including macrophages, a key …
Functions of double‐negative B cells in autoimmune diseases, infections, and cancers
Most mature B cells can be divided into four subtypes based on the expression of the
surface markers IgD and CD27: IgD+ CD27− naïve B cells, IgD+ CD27+ unswitched memory …
surface markers IgD and CD27: IgD+ CD27− naïve B cells, IgD+ CD27+ unswitched memory …
Th17 cytokines differentiate obesity from obesity‐associated type 2 diabetes and promote TNF α production
Objective T cell inflammation plays pivotal roles in obesity‐associated type 2 diabetes
(T2DM). The identification of dominant sources of T cell inflammation in humans remains a …
(T2DM). The identification of dominant sources of T cell inflammation in humans remains a …