Hydrophobicity: is LogPo/w more than the sum of its parts?

GE Kellogg, DJ Abraham - European journal of medicinal chemistry, 2000 - Elsevier
The empirically calculated parameter LogPo/w, the log10 of the coefficient for solvent
partitioning between 1-octanol and water, has been used to provide the key data for a …

Functional and structural diversity in the Als protein family of Candida albicans

DC Sheppard, MR Yeaman, WH Welch… - Journal of Biological …, 2004 - ASBMB
The human fungal pathogen Candida albicans colonizes and invades a wide range of host
tissues. Adherence to host constituents plays an important role in this process. Two …

[HTML][HTML] Molecular cloning of cDNA encoding a Drosophila ryanodine receptor and functional studies of the carboxyl-terminal calcium release channel

X Xu, MB Bhat, M Nishi, H Takeshima, J Ma - Biophysical Journal, 2000 - cell.com
Ryanodine is a plant alkaloid that was originally used as an insecticide. To study the
function and regulation of the ryanodine receptor (RyR) from insect cells, we have cloned …

[HTML][HTML] Role of the proposed pore-forming segment of the Ca2+ release channel (ryanodine receptor) in ryanodine interaction

SRW Chen, P Li, M Zhao, X Li, L Zhang - Biophysical journal, 2002 - cell.com
In earlier studies we showed that point mutations introduced into the proposed pore-forming
segment, GVRAGGGIGD (amino acids 4820–4829), of the mouse cardiac ryanodine …

Asymmetric Total Synthesis of (+)‐Ryanodol and (+)‐Ryanodine

K Masuda, M Koshimizu, M Nagatomo… - … –A European Journal, 2016 - Wiley Online Library
Ryanodine (1) is the ester derivative of 1H‐pyrrole‐2‐carboxylic acid and the complex
terpenoid (+)‐ryanodol (2), which possesses eleven contiguous stereogenic centers on the …

Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics

J Zheng, SMK McKinnie, A El Gamal… - … science & technology, 2018 - ACS Publications
Contemporary sources of organohalogens produced as disinfection byproducts (DBPs) are
receiving considerable attention as emerging pollutants because of their abundance …

Functional characterization of mutants in the predicted pore region of the rabbit cardiac muscle Ca2+ release channel (ryanodine receptor isoform 2)

GG Du, X Guo, VK Khanna, DH MacLennan - Journal of Biological …, 2001 - ASBMB
A highly conserved amino acid sequence, GVRAGGGIGD 4831, which may form part of the
Ca 2+ release channel pore in RyR2, was subjected to Ala scanning or Ala to Val …

[引用][C] The sarcoplasmic reticulum Ca2+ channel/ryanodine receptor: modulation by endogenous effectors, drugs and disease states

R Zucchi, S Ronca-Testoni - Pharmacological reviews, 1997 - ASPET

A ryanodine fluorescent derivative reveals the presence of high-affinity ryanodine binding sites in the Golgi complex of rat sympathetic neurons, with possible …

F Cifuentes, CE González, T Fiordelisio, G Guerrero… - Cellular signalling, 2001 - Elsevier
The plant alkaloid ryanodine (Ry) is a high-affinity modulator of ryanodine receptor (RyR)
Ca2+ release channels. Although these channels are present in a variety of cell types, their …

Structural components of ryanodine responsible for modulation of sarcoplasmic reticulum calcium channel function

W Welch, AJ Williams, A Tinker, KE Mitchell… - Biochemistry, 1997 - ACS Publications
Comparative molecular field analysis (CoMFA) was used to analyze the relationship
between the structure of a group of ryanoids and the modulation of the calcium channel …