The endocannabinoid system, consisting of the cannabinoid 1 receptor (CB 1 R) and
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …

Metamizole (dipyrone) is a popular analgetic, non-opioid drug, commonly used in human
and veterinary medicine. In some cases, this agent is still incorrectly classified as a non …

Accumulating evidence reveal important applications of endogenous pain modulation
assessment in healthy controls and in patients in clinical settings, as dysregulations in the …

Pain is a sensory and emotional experience that is substantially modulated by
psychological, social and contextual factors. Research now indicates that the influence of …

Pain is an ambiguous perception: the same pain stimulation can be perceived differently in
different contexts, producing different experiences, ranging from mild to unbearable pain. It …

For centuries, cannabis has been used with many different purposes, including medicinal
use, usually bypassing any formal approval process. However, during the last decade …

Background: Dipyrone (metamizole) is one of the most widely used non-opioid analgesics
for the treatment of cancer pain. Aim: Because evidence-based recommendations are not …

Purpose Nonopioid analgesics are frequently used for the treatment of acute and chronic
pain. Dipyrone is an alternative to NSAID s and paracetamol, however, data on the …

Although cannabis has been used for pain management for millennia, very few approved
cannabinoids are indicated for the treatment of pain and other medical symptoms …

Redundancy of metabolic pathways and molecular targets is a typical feature of all lipid
mediators, and endocannabinoids, which were originally defined as endogenous agonists …