Cancer vaccines exhibit specificity, effectiveness, and safety as an alternative
immunotherapeutic strategy to struggle against malignant diseases, especially with the rapid …

Memory T cells constitute the most abundant lymphocyte population in the body for the
majority of a person's lifetime; however, our understanding of memory T cell generation …

BACKGROUND. A defining pathophysiologic feature of sepsis is profound apoptosis-
induced death and depletion of CD4+ and CD8+ T cells. Interleukin-7 (IL-7) is an …

Antiretroviral therapy has revolutionized the course of HIV infection, improving immune
function and decreasing dramatically the mortality and morbidity due to the opportunistic …

Mast cells (MCs) are evolutionarily ancient innate immune cells with important roles in
protective immunity against bacteria, parasites, and venomous animals. They can be found …

HIV persists in latently infected memory CD4+ T cells during antiretroviral therapy (ART).
When administered to HIV-infected subjects receiving suppressive ART, interleukin-7 (IL-7) …

It remains unknown what causes inflammatory bowel disease (IBD), including signaling
networks perpetuating chronic gastrointestinal inflammation in Crohn's disease (CD) and …

There are limited data on fetal and early life development of human intestinal immunity.
Using mass cytometry (CyTOF) and next-generation sequencing of B and T cell receptor …

The intestinal microbiota determines immune responses against extraintestinal antigens,
including tumor-associated antigens. Indeed, depletion or gross perturbation of the …

Antiretroviral therapy (ART) is a life‐saving intervention in human immunodeficiency virus
(HIV) infection. Immune restoration after ART dramatically reduces the incidence and …