In order to ensure normal body function, the human body is dependent on a tight control of
its blood glucose levels. This is accomplished by a highly sophisticated network of various …

Metabolism research has made tremendous progress over the last several decades in
establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and …

The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

Puberty marks the end of childhood and is a period when individuals undergo physiological
and psychological changes to achieve sexual maturation and fertility. The hypothalamic …

▪ Abstract The discovery of the adipose-derived hormone leptin has generated enormous
interest in the interaction between peripheral signals and brain targets involved in the …

In muscle and fat cells, insulin stimulates the delivery of the glucose transporter GLUT4 from
an intracellular location to the cell surface, where it facilitates the reduction of plasma …

Leptin is hypothesized to function as a negative feedback signal in the regulation of energy
balance. It is produced primarily by adipose tissue and circulating concentrations correlate …

The polycystic ovary syndrome (PCOS) is a condition characterized by hyperandrogenism
and chronic oligo-anovulation. However, many features of the metabolic syndrome are …

Background The hormone leptin is an important regulator of metabolic homeostasis, able to
inhibit food intake and increase energy expenditure. Leptin can also independently lower …

III. IGFs and Their Receptors A. IGF peptides and receptors B. Expression of IGFs and IGF
receptors in the ovary C. Role of IGFs in ovulatory function and steroidogenesis