G-protein–coupled receptors signaling pathways in new antiplatelet drug development
Platelet G-protein–coupled receptors influence platelet function by mediating the response
to various agonists, including ADP, thromboxane A2, and thrombin. Blockade of the ADP …
to various agonists, including ADP, thromboxane A2, and thrombin. Blockade of the ADP …
Medicinal chemistry of P2 and adenosine receptors: Common scaffolds adapted for multiple targets
KA Jacobson, AP IJzerman, CE Müller - Biochemical pharmacology, 2021 - Elsevier
Abstract Prof. Geoffrey Burnstock originated the concept of purinergic signaling. He
demonstrated the interactions and biological roles of ionotropic P2X and metabotropic P2Y …
demonstrated the interactions and biological roles of ionotropic P2X and metabotropic P2Y …
Nucleotides acting at P2Y receptors: connecting structure and function
Eight G protein–coupled P2Y receptor (P2YR) subtypes are important physiologic
mediators. The human P2YRs are fully activated by ATP (P2Y2 and P2Y11), ADP (P2Y1 …
mediators. The human P2YRs are fully activated by ATP (P2Y2 and P2Y11), ADP (P2Y1 …
Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information
S Paoletta, D Sabbadin, I Von Kügelgen, S Hinz… - Journal of computer …, 2015 - Springer
The G protein-coupled P2Y 12 receptor (P2Y 12 R) is an important antithrombotic target and
of great interest for pharmaceutical discovery. Its recently solved, highly divergent …
of great interest for pharmaceutical discovery. Its recently solved, highly divergent …
New highly active antiplatelet agents with dual specificity for platelet P2Y1 and P2Y12 adenosine diphosphate receptors
IB Yanachkov, H Chang, MI Yanachkova, EJ Dix… - European journal of …, 2016 - Elsevier
Currently approved platelet adenosine diphosphate (ADP) receptor antagonists target only
the platelet P2Y 12 receptor. Moreover, especially in patients with acute coronary …
the platelet P2Y 12 receptor. Moreover, especially in patients with acute coronary …
[HTML][HTML] GLS-409, an Antagonist of Both P2Y1 and P2Y12, Potently Inhibits Canine Coronary Artery Thrombosis and Reversibly Inhibits Human Platelet Activation
E Smolensky Koganov, AD Michelson, IB Yanachkov… - Scientific Reports, 2018 - nature.com
Dual antiplatelet therapy with aspirin and an adenosine diphosphate (ADP) P2Y12 receptor
antagonist reduces ischemic events in patients with acute coronary syndrome. Previous …
antagonist reduces ischemic events in patients with acute coronary syndrome. Previous …
Novel antiplatelet agents in cardiovascular medicine
Opinion statement Dual antiplatelet therapy with aspirin and a P2Y 12 receptor blocker,
particularly clopidogrel, has been the standard of therapy for secondary prevention in …
particularly clopidogrel, has been the standard of therapy for secondary prevention in …
[HTML][HTML] Ap4A Regulates Directional Mobility and Antigen Presentation in Dendritic Cells
The significance of intracellular Ap 4 A levels over immune activity of dendritic cells (DCs)
has been studied in Nudt2 fl/fl/CD11c-cre mice. The transgenic mice have been generated …
has been studied in Nudt2 fl/fl/CD11c-cre mice. The transgenic mice have been generated …
New Tools to Study ApnAs in Eukaryotic and Prokaryotic Systems
KH Götz - 2018 - kops.uni-konstanz.de
The survival and accurate development of cells and whole organisms is ensured by a great
number of biochemical processes and pathways. Many of them are linked with each other …
number of biochemical processes and pathways. Many of them are linked with each other …