Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways
involved in numerous physiological processes (eg, vasodilation, neurotransmission …

CaMKII (the multifunctional Ca2+ and calmodulin-dependent protein kinase II) is a highly
validated signal for promoting a variety of common diseases, particularly in the …

Nitric oxide (NO) is one of the critical components of the vasculature, regulating key
signaling pathways in health. In macrovessels, NO functions to suppress cell inflammation …

Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …

Rationale: Diabetes mellitus is a complex, multisystem disease, affecting large populations
worldwide. Chronic CaMKII (Ca2+/calmodulin-dependent kinase II) activation may occur in …

The cardiac field has benefited from the availability of several CaMKII inhibitors serving as
research tools to test putative CaMKII pathways associated with cardiovascular physiology …

Calcium/calmodulin (Ca2+/CaM) dependent protein kinase II (CaMKII) has emerged as a
key nodal protein in the regulation of cardiac physiology and pathology. Due to the …

Calcium and redox signaling both play important roles in the pathogenesis of cardiac
disease; although how these signals are integrated in the heart remains unclear. One …

Abstract Sustained Ca 2+/calmodulin-dependent kinase II (CaMKII) activation plays a central
role in the pathogenesis of a variety of cardiac diseases. Emerging evidence suggests …

Despite improvements in the therapy of underlying heart disease, sudden cardiac death is a
major cause of death worldwide. Disturbed Na and Ca handling is known to be a major …