Nitric oxide: physiological functions, delivery, and biomedical applications
Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways
involved in numerous physiological processes (eg, vasodilation, neurotransmission …
involved in numerous physiological processes (eg, vasodilation, neurotransmission …
CaMKII as a therapeutic target in cardiovascular disease
OE Reyes Gaido, LJ Nkashama… - Annual review of …, 2023 - annualreviews.org
CaMKII (the multifunctional Ca2+ and calmodulin-dependent protein kinase II) is a highly
validated signal for promoting a variety of common diseases, particularly in the …
validated signal for promoting a variety of common diseases, particularly in the …
Nitric oxide: what's new to NO?
K Ghimire, HM Altmann, AC Straub… - American Journal of …, 2017 - journals.physiology.org
Nitric oxide (NO) is one of the critical components of the vasculature, regulating key
signaling pathways in health. In macrovessels, NO functions to suppress cell inflammation …
signaling pathways in health. In macrovessels, NO functions to suppress cell inflammation …
Calcium signaling and transcriptional regulation in cardiomyocytes
M Dewenter, A von der Lieth, HA Katus… - Circulation …, 2017 - Am Heart Assoc
Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …
Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O-linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes
S Lu, Z Liao, X Lu, DM Katschinski, M Mercola… - Circulation …, 2020 - Am Heart Assoc
Rationale: Diabetes mellitus is a complex, multisystem disease, affecting large populations
worldwide. Chronic CaMKII (Ca2+/calmodulin-dependent kinase II) activation may occur in …
worldwide. Chronic CaMKII (Ca2+/calmodulin-dependent kinase II) activation may occur in …
CaMKII inhibitors: from research tools to therapeutic agents
P Pellicena, H Schulman - Frontiers in pharmacology, 2014 - frontiersin.org
The cardiac field has benefited from the availability of several CaMKII inhibitors serving as
research tools to test putative CaMKII pathways associated with cardiovascular physiology …
research tools to test putative CaMKII pathways associated with cardiovascular physiology …
Mechanisms of CaMKII activation in the heart
JR Erickson - Frontiers in pharmacology, 2014 - frontiersin.org
Calcium/calmodulin (Ca2+/CaM) dependent protein kinase II (CaMKII) has emerged as a
key nodal protein in the regulation of cardiac physiology and pathology. Due to the …
key nodal protein in the regulation of cardiac physiology and pathology. Due to the …
CaMKII oxidative activation and the pathogenesis of cardiac disease
ED Luczak, ME Anderson - Journal of molecular and cellular cardiology, 2014 - Elsevier
Calcium and redox signaling both play important roles in the pathogenesis of cardiac
disease; although how these signals are integrated in the heart remains unclear. One …
disease; although how these signals are integrated in the heart remains unclear. One …
CaMKII is a nodal signal for multiple programmed cell death pathways in heart
N Feng, ME Anderson - Journal of molecular and cellular cardiology, 2017 - Elsevier
Abstract Sustained Ca 2+/calmodulin-dependent kinase II (CaMKII) activation plays a central
role in the pathogenesis of a variety of cardiac diseases. Emerging evidence suggests …
role in the pathogenesis of a variety of cardiac diseases. Emerging evidence suggests …
Role of sodium and calcium dysregulation in tachyarrhythmias in sudden cardiac death
Despite improvements in the therapy of underlying heart disease, sudden cardiac death is a
major cause of death worldwide. Disturbed Na and Ca handling is known to be a major …
major cause of death worldwide. Disturbed Na and Ca handling is known to be a major …